Cargando…
Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
Altered mitochondria activity in osteoblasts and osteoclasts has been implicated in the loss of bone mass associated with aging and estrogen deficiency — the 2 most common causes of osteoporosis. However, the mechanisms that control mitochondrial metabolism in bone cells during health or disease rem...
Autores principales: | Ling, Wen, Krager, Kimberly, Richardson, Kimberly K., Warren, Aaron D., Ponte, Filipa, Aykin-Burns, Nukhet, Manolagas, Stavros C., Almeida, Maria, Kim, Ha-Neui |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262324/ https://www.ncbi.nlm.nih.gov/pubmed/33878033 http://dx.doi.org/10.1172/jci.insight.146728 |
Ejemplares similares
-
Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
por: Kim, Ha-Neui, et al.
Publicado: (2021) -
Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors
por: Kim, Ha-Neui, et al.
Publicado: (2020) -
Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
por: Richardson, Kimberly K., et al.
Publicado: (2022) -
Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency
por: Ponte, Filipa, et al.
Publicado: (2022) -
Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
por: Wang, Xiaoyan, et al.
Publicado: (2022)