Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth

Activating mutations in fibroblast growth factor receptor 3 (FGFR3) and inactivating mutations in the natriuretic peptide receptor 2 (NPR2) guanylyl cyclase both result in decreased production of cyclic GMP in chondrocytes and severe short stature, causing achondroplasia (ACH) and acromesomelic dysp...

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Detalles Bibliográficos
Autores principales: Shuhaibar, Leia C., Kaci, Nabil, Egbert, Jeremy R., Horville, Thibault, Loisay, Léa, Vigone, Giulia, Uliasz, Tracy F., Dambroise, Emilie, Swingle, Mark R., Honkanen, Richard E., Duplan, Martin Biosse, Jaffe, Laurinda A., Legeai-Mallet, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262325/
https://www.ncbi.nlm.nih.gov/pubmed/33986191
http://dx.doi.org/10.1172/jci.insight.141426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262325/
https://www.ncbi.nlm.nih.gov/pubmed/33986191
http://dx.doi.org/10.1172/jci.insight.141426

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