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Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging

The omega-3 fatty acid docosahexaenoic acid (DHA) inversely relates to neurological impairments with aging; however, limited nondietary models manipulating brain DHA have hindered a direct linkage. We discovered that loss of long-chain acyl-CoA synthetase 6 in mice (Acsl6(–/–)) depletes brain membra...

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Detalles Bibliográficos
Autores principales:	Fernandez, Regina F., Pereyra, Andrea S., Diaz, Victoria, Wilson, Emily S., Litwa, Karen A., Martínez-Gardeazabal, Jonatan, Jackson, Shelley N., Brenna, J. Thomas, Hermann, Brian P., Eells, Jeffrey B., Ellis, Jessica M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262339/ https://www.ncbi.nlm.nih.gov/pubmed/34100386 http://dx.doi.org/10.1172/jci.insight.144351

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