Cargando…

11-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration

BACKGROUND: Continued androgen receptor (AR) signaling constitutes a key target for treatment in metastatic castration-resistant prostate cancer (CRPC). Studies have identified 11-ketotestosterone (11KT) as a potent AR agonist, but it is unknown if 11KT is present at physiologically relevant concent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Snaterse, Gido, van Dessel, Lisanne F., van Riet, Job, Taylor, Angela E., van der Vlugt-Daane, Michelle, Hamberg, Paul, de Wit, Ronald, Visser, Jenny A., Arlt, Wiebke, Lolkema, Martijn P., Hofland, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Clinical Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262344/ https://www.ncbi.nlm.nih.gov/pubmed/33974560 http://dx.doi.org/10.1172/jci.insight.148507

Ejemplares similares

SAT-LB002 Steroid Metabolome Analysis Reveals 11-Ketotestosterone as the Most Abundant Androgen in Castration-Resistant Prostate Cancer Patients on Second-Line Therapies
por: Snaterse, Gido, et al.
Publicado: (2019)

The role of 11-oxygenated androgens in prostate cancer
por: Snaterse, Gido, et al.
Publicado: (2023)

A Compendium of AR Splice Variants in Metastatic Castration-Resistant Prostate Cancer
por: Isebia, Khrystany T., et al.
Publicado: (2023)

11-Ketotestosterone and 11-Ketodihydrotestosterone in Castration Resistant Prostate Cancer: Potent Androgens Which Can No Longer Be Ignored
por: Pretorius, Elzette, et al.
Publicado: (2016)

ODP435 11-Ketotestosterone is One of the Major Androgens in Pigs
por: Yazawa, Takashi, et al.
Publicado: (2022)

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
por: van Dessel, Lisanne F., et al.
Publicado: (2019)

Abiraterone switches castration‐resistant prostate cancer dependency from adrenal androgens towards androgen receptor variants and glucocorticoid receptor signalling
por: Moll, J. Matthijs, et al.
Publicado: (2022)

SAT024 Contribution of 11-Ketotestosterone and 11-Ketodihydrotestosterone to Castration-Resistant Prostate Cancer
por: Abu-Lebdeh, Haitham S, et al.
Publicado: (2023)

Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosterone
por: Olsson, Per-Erik, et al.
Publicado: (2005)

Androgen receptor signalling impairs docetaxel efficacy in castration-resistant prostate cancer
por: Mout, Lisanne, et al.
Publicado: (2020)

Circulating Tumor Cell Enumeration and Characterization in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Cabazitaxel
por: de Kruijff, Ingeborg E., et al.
Publicado: (2019)

High‐throughput isolation of circulating tumor DNA: a comparison of automated platforms
por: van Dessel, Lisanne F., et al.
Publicado: (2018)

11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome
por: O’Reilly, Michael W., et al.
Publicado: (2016)

Detection of tumor-derived extracellular vesicles in plasma from patients with solid cancer
por: Vitale, Silvia R., et al.
Publicado: (2021)

Effects of 11-Ketotestosterone on Development of the Previtellogenic Ovary in the Sterlet, Acipenser ruthenus
por: Wang, Wei, et al.
Publicado: (2020)

MON-203 Local Activation of 11-Oxygenated Androgens by AKR1C3 Is the Predominant Source of Androgens in Human Female Adipose Tissue
por: Schiffer, Lina, et al.
Publicado: (2019)

Predicting response to enzalutamide and abiraterone in metastatic prostate cancer using whole-omics machine learning
por: de Jong, Anouk C., et al.
Publicado: (2023)

SUN-208 The Intra-Individual Variability of 11-Ketotestosterone and 11β-Hydroxyandrostenedione
por: Hawley, James, et al.
Publicado: (2020)

Continued Androgen Signalling Inhibition improves Cabazitaxel Efficacy in Prostate Cancer
por: Mout, Lisanne, et al.
Publicado: (2021)

Male convict cichlid 11-ketotestosterone levels throughout the reproductive cycle: an exploratory profile study in laboratory and field populations
por: van Breukelen, Natalie April, et al.
Publicado: (2015)

Bpifcl modulates kiss2 expression under the influence of 11-ketotestosterone in female zebrafish
por: Moriya, Shogo, et al.
Publicado: (2017)

Adrenal gland involvement in 11-ketotestosterone production analyzed using LC-MS/MS
por: Ikegawa, Kento, et al.
Publicado: (2023)

Intracrine androgen biosynthesis, metabolism and action revisited
por: Schiffer, Lina, et al.
Publicado: (2018)

The Steroid Metabolome in the Isolated Ovarian Follicle and Its Response to Androgen Exposure and Antagonism
por: Lebbe, Marie, et al.
Publicado: (2017)

Testosterone Diminishes Cabazitaxel Efficacy and Intratumoral Accumulation in a Prostate Cancer Xenograft Model()
por: Mout, Lisanne, et al.
Publicado: (2017)

Application of circulating tumor DNA in prospective clinical oncology trials – standardization of preanalytical conditions
por: van Dessel, Lisanne F., et al.
Publicado: (2017)

Androgens as therapy for androgen receptor-positive castration-resistant prostate cancer
por: Chuu, Chih-Pin, et al.
Publicado: (2011)

mFast‐SeqS‐based aneuploidy score in circulating cell‐free DNA is a prognostic biomarker in prostate cancer
por: Isebia, Khrystany T., et al.
Publicado: (2023)

Prognostic factors in men with metastatic castration-resistant prostate cancer treated with cabazitaxel
por: Belderbos, Bodine P.S., et al.
Publicado: (2017)

SAT-004 The Development And Application Of An Lc-ms/ms Method To Investigate The Stability Of 11β-hydroxyandrostenedione And 11-ketotestosterone.
por: Hawley, James
Publicado: (2019)

Effects of estradiol and 11-ketotestosterone pre-treatment on artificial induction of maturation in silver female shortfinned eels (Anguilla australis)
por: Damsteegt, Erin L., et al.
Publicado: (2020)

Case report: 11-ketotestosterone may potentiate advanced bone age as seen in some cases of Wiedemann-Steiner Syndrome
por: Buchanan, Katherine, et al.
Publicado: (2022)

MECHANISMS IN ENDOCRINOLOGY: The sexually dimorphic role of androgens in human metabolic disease
por: Schiffer, Lina, et al.
Publicado: (2017)

Patient-Derived Xenografts and Organoids Recapitulate Castration-Resistant Prostate Cancer with Sustained Androgen Receptor Signaling
por: Van Hemelryk, Annelies, et al.
Publicado: (2022)

Implicating androgen excess in propagating metabolic disease in polycystic ovary syndrome
por: Kempegowda, Punith, et al.
Publicado: (2020)

Characterizing Circulating Tumor Cells and Tumor-Derived Extracellular Vesicles in Metastatic Castration-Naive and Castration-Resistant Prostate Cancer Patients
por: Isebia, Khrystany T., et al.
Publicado: (2022)

Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer
por: Stein, Mark N, et al.
Publicado: (2014)

Persistent androgen receptor addiction in castration-resistant prostate cancer
por: Schweizer, Michael T., et al.
Publicado: (2015)

The expression of AURKA is androgen regulated in castration-resistant prostate cancer
por: Kivinummi, Kati, et al.
Publicado: (2017)

Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer
por: Feng, Qin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0lmhd3g29jcmml03i1pktt4gj0