Direct imaging of glymphatic transport using H(2)(17)O MRI

The recently proposed glymphatic pathway for solute transport and waste clearance from the brain has been the focus of intense debate. By exploiting an isotopically enriched MRI tracer, H(2)(17)O, we directly imaged glymphatic water transport in the rat brain in vivo. Our results reveal glymphatic t...

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Detalles Bibliográficos
Autores principales: Alshuhri, Mohammed S., Gallagher, Lindsay, Work, Lorraine M., Holmes, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262348/
https://www.ncbi.nlm.nih.gov/pubmed/33857020
http://dx.doi.org/10.1172/jci.insight.141159
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author Alshuhri, Mohammed S.
Gallagher, Lindsay
Work, Lorraine M.
Holmes, William M.
author_facet Alshuhri, Mohammed S.
Gallagher, Lindsay
Work, Lorraine M.
Holmes, William M.
author_sort Alshuhri, Mohammed S.
collection PubMed
description The recently proposed glymphatic pathway for solute transport and waste clearance from the brain has been the focus of intense debate. By exploiting an isotopically enriched MRI tracer, H(2)(17)O, we directly imaged glymphatic water transport in the rat brain in vivo. Our results reveal glymphatic transport that is dramatically faster and more extensive than previously thought and unlikely to be explained by diffusion alone. Moreover, we confirm the critical role of aquaporin-4 channels in glymphatic transport.
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spelling pubmed-82623482021-07-13 Direct imaging of glymphatic transport using H(2)(17)O MRI Alshuhri, Mohammed S. Gallagher, Lindsay Work, Lorraine M. Holmes, William M. JCI Insight Technical Advance The recently proposed glymphatic pathway for solute transport and waste clearance from the brain has been the focus of intense debate. By exploiting an isotopically enriched MRI tracer, H(2)(17)O, we directly imaged glymphatic water transport in the rat brain in vivo. Our results reveal glymphatic transport that is dramatically faster and more extensive than previously thought and unlikely to be explained by diffusion alone. Moreover, we confirm the critical role of aquaporin-4 channels in glymphatic transport. American Society for Clinical Investigation 2021-05-24 /pmc/articles/PMC8262348/ /pubmed/33857020 http://dx.doi.org/10.1172/jci.insight.141159 Text en © 2021 Alshuhri et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Technical Advance
Alshuhri, Mohammed S.
Gallagher, Lindsay
Work, Lorraine M.
Holmes, William M.
Direct imaging of glymphatic transport using H(2)(17)O MRI
title Direct imaging of glymphatic transport using H(2)(17)O MRI
title_full Direct imaging of glymphatic transport using H(2)(17)O MRI
title_fullStr Direct imaging of glymphatic transport using H(2)(17)O MRI
title_full_unstemmed Direct imaging of glymphatic transport using H(2)(17)O MRI
title_short Direct imaging of glymphatic transport using H(2)(17)O MRI
title_sort direct imaging of glymphatic transport using h(2)(17)o mri
topic Technical Advance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262348/
https://www.ncbi.nlm.nih.gov/pubmed/33857020
http://dx.doi.org/10.1172/jci.insight.141159
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