The impact of tumor epithelial and microenvironmental heterogeneity on treatment responses in HER2(+) breast cancer

Despite the availability of multiple human epidermal growth factor receptor 2–targeted (HER2-targeted) treatments, therapeutic resistance in HER2(+) breast cancer remains a clinical challenge. Intratumor heterogeneity for HER2 and resistance-conferring mutations in the PIK3CA gene (encoding PI3K cat...

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Detalles Bibliográficos
Autores principales: Janiszewska, Michalina, Stein, Shayna, Metzger Filho, Otto, Eng, Jennifer, Kingston, Natalie L., Harper, Nicholas W., Rye, Inga H., Alečković, Maša, Trinh, Anne, Murphy, Katherine C., Marangoni, Elisabetta, Cristea, Simona, Oakes, Benjamin, Winer, Eric P., Krop, Ian E., Russnes, Hege G., Spellman, Paul T., Bucher, Elmar, Hu, Zhi, Chin, Koei, Gray, Joe W., Michor, Franziska, Polyak, Kornelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262355/
https://www.ncbi.nlm.nih.gov/pubmed/33886505
http://dx.doi.org/10.1172/jci.insight.147617

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