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Thyroid hormone synthesis continues despite biallelic thyroglobulin mutation with cell death

Complete absence of thyroid hormone is incompatible with life in vertebrates. Thyroxine is synthesized within thyroid follicles upon iodination of thyroglobulin conveyed from the endoplasmic reticulum (ER), via the Golgi complex, to the extracellular follicular lumen. In congenital hypothyroidism fr...

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Detalles Bibliográficos
Autores principales:	Zhang, Xiaohan, Kellogg, Aaron P., Citterio, Cintia E., Zhang, Hao, Larkin, Dennis, Morishita, Yoshiaki, Targovnik, Héctor M., Balbi, Viviana A., Arvan, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262357/ https://www.ncbi.nlm.nih.gov/pubmed/33914707 http://dx.doi.org/10.1172/jci.insight.148496

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