Cargando…
B cell–activating factor modulates the factor VIII immune response in hemophilia A
Inhibitors of factor VIII (FVIII) remain the most challenging complication of FVIII protein replacement therapy in hemophilia A (HA). Understanding the mechanisms that guide FVIII-specific B cell development could help identify therapeutic targets. The B cell–activating factor (BAFF) cytokine family...
Autores principales: | Doshi, Bhavya S., Rana, Jyoti, Castaman, Giancarlo, Shaheen, Mostafa A., Kaczmarek, Radoslaw, Butterfield, John S.S., Meeks, Shannon L., Leissinger, Cindy, Biswas, Moanaro, Arruda, Valder R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262462/ https://www.ncbi.nlm.nih.gov/pubmed/33651716 http://dx.doi.org/10.1172/JCI142906 |
Ejemplares similares
-
Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A
por: Sherman, Alexandra, et al.
Publicado: (2017) -
Potentiation of Thrombin Generation in Hemophilia A Plasma by Coagulation Factor VIII and Characterization of Antibody-Specific Inhibition
por: Doshi, Bhavya S., et al.
Publicado: (2012) -
Gene Therapy for Hemophilia: Facts and Quandaries in the 21st Century
por: Arruda, Valder R., et al.
Publicado: (2020) -
Emerging therapies for hemophilia: controversies and unanswered questions
por: Arruda, Valder R., et al.
Publicado: (2018) -
Human von Willebrand factor/factor VIII concentrates in the management of pediatric patients with von Willebrand disease/hemophilia A
por: Castaman, Giancarlo, et al.
Publicado: (2016)