Mice with induced pulmonary morbidities display severe lung inflammation and mortality following exposure to SARS-CoV-2

Mice are normally unaffected by SARS coronavirus 2 (SARS-CoV-2) infection since the virus does not bind effectively to the murine version of the angiotensin-converting enzyme 2 (ACE2) receptor molecule. Here, we report that induced mild pulmonary morbidities rendered SARS-CoV-2–refractive CD-1 mice...

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Detalles Bibliográficos
Autores principales: Falach, Reut, Bar-On, Liat, Lazar, Shlomi, Kadar, Tamar, Mazor, Ohad, Aftalion, Moshe, Gur, David, Evgy, Yentl, Shifman, Ohad, Aminov, Tamar, Israeli, Ofir, Cohen-Gihon, Inbar, Zaide, Galia, Gutman, Hila, Vagima, Yaron, Makdasi, Efi, Stein, Dana, Rosenfeld, Ronit, Alcalay, Ron, Zahavy, Eran, Levy, Haim, Glinert, Itai, Ben-Shmuel, Amir, Israely, Tomer, Melamed, Sharon, Politi, Boaz, Achdout, Hagit, Yitzhaki, Shmuel, Kronman, Chanoch, Sabo, Tamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262502/
https://www.ncbi.nlm.nih.gov/pubmed/33974566
http://dx.doi.org/10.1172/jci.insight.145916

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