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OmicsAnalyst: a comprehensive web-based platform for visual analytics of multi-omics data

Data analysis and interpretation remain a critical bottleneck in current multi-omics studies. Here, we introduce OmicsAnalyst, a user-friendly, web-based platform that allows users to perform a wide range of well-established data-driven approaches for multi-omics integration, and visually explore th...

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Detalles Bibliográficos
Autores principales: Zhou, Guangyan, Ewald, Jessica, Xia, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262745/
https://www.ncbi.nlm.nih.gov/pubmed/34019646
http://dx.doi.org/10.1093/nar/gkab394
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author Zhou, Guangyan
Ewald, Jessica
Xia, Jianguo
author_facet Zhou, Guangyan
Ewald, Jessica
Xia, Jianguo
author_sort Zhou, Guangyan
collection PubMed
description Data analysis and interpretation remain a critical bottleneck in current multi-omics studies. Here, we introduce OmicsAnalyst, a user-friendly, web-based platform that allows users to perform a wide range of well-established data-driven approaches for multi-omics integration, and visually explore their results in a clear and meaningful manner. To help navigate complex landscapes of multi-omics analysis, these approaches are organized into three visual analytics tracks: (i) the correlation network analysis track, where users choose among univariate and multivariate methods to identify important features and explore their relationships in 2D or 3D networks; (ii) the cluster heatmap analysis track, where users apply several cutting-edge multi-view clustering algorithms and explore their results via interactive heatmaps; and (iii) the dimension reduction analysis track, where users choose among several recent multivariate techniques to reveal global data structures, and explore corresponding scores, loadings and biplots in interactive 3D scatter plots. The three visual analytics tracks are equipped with comprehensive options for parameter customization, view customization and targeted analysis. OmicsAnalyst lowers the access barriers to many well-established methods for multi-omics integration via novel visual analytics. It is freely available at https://www.omicsanalyst.ca.
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spelling pubmed-82627452021-07-08 OmicsAnalyst: a comprehensive web-based platform for visual analytics of multi-omics data Zhou, Guangyan Ewald, Jessica Xia, Jianguo Nucleic Acids Res Web Server Issue Data analysis and interpretation remain a critical bottleneck in current multi-omics studies. Here, we introduce OmicsAnalyst, a user-friendly, web-based platform that allows users to perform a wide range of well-established data-driven approaches for multi-omics integration, and visually explore their results in a clear and meaningful manner. To help navigate complex landscapes of multi-omics analysis, these approaches are organized into three visual analytics tracks: (i) the correlation network analysis track, where users choose among univariate and multivariate methods to identify important features and explore their relationships in 2D or 3D networks; (ii) the cluster heatmap analysis track, where users apply several cutting-edge multi-view clustering algorithms and explore their results via interactive heatmaps; and (iii) the dimension reduction analysis track, where users choose among several recent multivariate techniques to reveal global data structures, and explore corresponding scores, loadings and biplots in interactive 3D scatter plots. The three visual analytics tracks are equipped with comprehensive options for parameter customization, view customization and targeted analysis. OmicsAnalyst lowers the access barriers to many well-established methods for multi-omics integration via novel visual analytics. It is freely available at https://www.omicsanalyst.ca. Oxford University Press 2021-05-21 /pmc/articles/PMC8262745/ /pubmed/34019646 http://dx.doi.org/10.1093/nar/gkab394 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Web Server Issue
Zhou, Guangyan
Ewald, Jessica
Xia, Jianguo
OmicsAnalyst: a comprehensive web-based platform for visual analytics of multi-omics data
title OmicsAnalyst: a comprehensive web-based platform for visual analytics of multi-omics data
title_full OmicsAnalyst: a comprehensive web-based platform for visual analytics of multi-omics data
title_fullStr OmicsAnalyst: a comprehensive web-based platform for visual analytics of multi-omics data
title_full_unstemmed OmicsAnalyst: a comprehensive web-based platform for visual analytics of multi-omics data
title_short OmicsAnalyst: a comprehensive web-based platform for visual analytics of multi-omics data
title_sort omicsanalyst: a comprehensive web-based platform for visual analytics of multi-omics data
topic Web Server Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262745/
https://www.ncbi.nlm.nih.gov/pubmed/34019646
http://dx.doi.org/10.1093/nar/gkab394
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