Cargando…

The Toxoplasma Polymorphic Effector GRA15 Mediates Seizure Induction by Modulating Interleukin-1 Signaling in the Brain

Toxoplasmic encephalitis can develop in individuals infected with the protozoan parasite Toxoplasma gondii and is typified by parasite replication and inflammation within the brain. Patients often present with seizures, but the parasite genes and host pathways involved in seizure development and/or...

Descripción completa

Detalles Bibliográficos
Autores principales:	Glausen, Taylor G., Carrillo, Gabriela L., Jin, Richard M., Boyle, Jon P., Saeij, Jeroen P. J., Wohlfert, Elizabeth A., Fox, Michael A., Blader, Ira J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262954/ https://www.ncbi.nlm.nih.gov/pubmed/34154412 http://dx.doi.org/10.1128/mBio.01331-21

Ejemplares similares

Toxoplasma Does Not Secrete the GRA16 and GRA24 Effectors Beyond the Parasitophorous Vacuole Membrane of Tissue Cysts
por: Krishnamurthy, Shruthi, et al.
Publicado: (2018)

Toxoplasma GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11
por: Mukhopadhyay, Debanjan, et al.
Publicado: (2020)

Toxoplasma GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors
por: Sangaré, Lamba Omar, et al.
Publicado: (2019)

Strain-specific activation of the NF-κB pathway by GRA15, a novel Toxoplasma gondii dense granule protein
por: Rosowski, Emily E., et al.
Publicado: (2011)

Toxoplasma GRA Peptide-Specific Serologic Fingerprints Discriminate Among Major Strains Causing Toxoplasmosis
por: Arranz-Solís, David, et al.
Publicado: (2021)

Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neurons
por: Bando, Hironori, et al.
Publicado: (2019)

Identification of host proteins interacting with Toxoplasma gondii GRA15 (TgGRA15) by yeast two-hybrid system
por: Liu, Qing, et al.
Publicado: (2017)

Toxoplasma gondii GRA28 Is Required for Placenta-Specific Induction of the Regulatory Chemokine CCL22 in Human and Mouse
por: Rudzki, Elizabeth N., et al.
Publicado: (2021)

Genome-wide CRISPR screen identifies genes synthetically lethal with GRA17, a nutrient channel encoding gene in Toxoplasma
por: Paredes-Santos, Tatiana C., et al.
Publicado: (2023)

The Toxoplasma gondii effector GRA83 modulates the host’s innate immune response to regulate parasite infection
por: Thind, Amara C., et al.
Publicado: (2023)

Differential Impacts on Host Transcription by ROP and GRA Effectors from the Intracellular Parasite Toxoplasma gondii
por: Rastogi, Suchita, et al.
Publicado: (2020)

The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability
por: Paredes-Santos, Tatiana, et al.
Publicado: (2019)

Toxoplasma gondii Matrix Antigen 1 Is a Secreted Immunomodulatory Effector
por: Tomita, Tadakimi, et al.
Publicado: (2021)

Toxoplasma effector-induced ICAM-1 expression by infected dendritic cells potentiates transmigration across polarised endothelium
por: Ross, Emily C., et al.
Publicado: (2022)

Evaluation of recombinant granule antigens GRA1 and GRA7 for serodiagnosis of Toxoplasma gondii infection in dogs
por: Wang, Zedong, et al.
Publicado: (2014)

Toxoplasma gondii Clonal Strains All Inhibit STAT1 Transcriptional Activity but Polymorphic Effectors Differentially Modulate IFNγ Induced Gene Expression and STAT1 Phosphorylation
por: Rosowski, Emily E., et al.
Publicado: (2012)

Protective efficacy of Toxoplasma gondii GRA12 or GRA7 recombinant proteins encapsulated in PLGA nanoparticles against acute Toxoplasma gondii infection in mice
por: Sun, Hong-chao, et al.
Publicado: (2023)

Toxoplasma gondii Infections Alter GABAergic Synapses and Signaling in the Central Nervous System
por: Brooks, Justin M., et al.
Publicado: (2015)

Human Innate Immunity to Toxoplasma gondii Is Mediated by Host Caspase-1 and ASC and Parasite GRA15
por: Gov, Lanny, et al.
Publicado: (2013)

Toxoplasma Uses GRA16 To Upregulate Host c-Myc
por: Panas, Michael W., et al.
Publicado: (2020)

Protective immunity induced by DNA vaccine containing TgGRA35, TgGRA42, and TgGRA43 against Toxoplasma gondii infection in Kunming mice
por: Shi, Youbo, et al.
Publicado: (2023)

Cloning, expression and immunoreactivity of recombinant Toxoplasma gondii GRA5 protein
por: Arab-Mazar, Zahra, et al.
Publicado: (2016)

A Family of Toxoplasma gondii Genes Related to GRA12 Regulate Cyst Burdens and Cyst Reactivation
por: Guevara, Rebekah B., et al.
Publicado: (2021)

New Avenues to Design Toxoplasma Vaccines Based on Oocysts and Cysts
por: Arranz-Solís, David, et al.
Publicado: (2022)

Effective Amelioration of Liver Fibrosis Through Lentiviral Vector Carrying Toxoplasma gondii gra15(II) in Murine Model
por: Liu, Lei, et al.
Publicado: (2018)

The role of DNA microarrays in Toxoplasma gondii research, the causative agent of ocular toxoplasmosis
por: Brown, Kevin M., et al.
Publicado: (2009)

Production and Evaluation of Toxoplasma gondii Recombinant GRA7 for Serodiagnosis of Human Infections
por: Selseleh, Mina, et al.
Publicado: (2012)

Identifying Novel B Cell Epitopes within Toxoplasma gondii GRA6
por: Wang, Yanhua, et al.
Publicado: (2016)

Increase in the nuclear localization of PTEN by the Toxoplasma GRA16 protein and subsequent induction of p53‐dependent apoptosis and anticancer effect
por: Kim, Sang‐Gyun, et al.
Publicado: (2019)

The Secreted Acid Phosphatase Domain-Containing GRA44 from Toxoplasma gondii Is Required for c-Myc Induction in Infected Cells
por: Blakely, William J., et al.
Publicado: (2020)

Toxoplasma gondii gra5 deletion mutant protects hosts against Toxoplasma gondii infection and breast tumors
por: Chen, Min, et al.
Publicado: (2023)

Testing New Peptides From Toxoplasma gondii SAG1, GRA6, and GRA7 for Serotyping: Better Definition Using GRA6 in Mother/Newborns Pairs With Risk of Congenital Transmission in Mexico
por: Xicoténcatl-García, Lizbeth, et al.
Publicado: (2019)

Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death
por: Saeij, Jeroen P, et al.
Publicado: (2017)

Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection
por: Mukhopadhyay, Debanjan, et al.
Publicado: (2020)

CRISPR screen to determine the in vivo fitness of Toxoplasma genes
por: Sangaré, Lamba Omar, et al.
Publicado: (2021)

Expression and Single-step Purification of GRA8 Antigen of Toxoplasma gondii in Escherichia coli
por: Babaie, Jalal, et al.
Publicado: (2011)

Analyzing and identifying novel B cell epitopes within Toxoplasma gondii GRA4
por: Wang, Yanhua, et al.
Publicado: (2014)

Development and evaluation of recombinant GRA8 protein for the serodiagnosis of Toxoplasma gondii infection in goats
por: Jirapattharasate, Charoonluk, et al.
Publicado: (2021)

Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis
por: Wang, Yifan, et al.
Publicado: (2019)

Phenotypes Associated with Knockouts of Eight Dense Granule Gene Loci (GRA2-9) in Virulent Toxoplasma gondii
por: Rommereim, Leah M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_c559ql9brnhvfuuqil933rnf3a