The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts

Interferon-stimulated gene products (ISGs) play a crucial role in early infection control. The ISG zinc finger CCCH-type antiviral protein 1 (ZAP/ZC3HAV1) antagonizes several RNA viruses by binding to CG-rich RNA sequences, whereas its effect on DNA viruses is less well understood. Here, we decipher...

Descripción completa

Detalles Bibliográficos
Autores principales: Gonzalez-Perez, Ana Cristina, Stempel, Markus, Wyler, Emanuel, Urban, Christian, Piras, Antonio, Hennig, Thomas, Ganskih, Sabina, Wei, Yuanjie, Heim, Albert, Landthaler, Markus, Pichlmair, Andreas, Dölken, Lars, Munschauer, Mathias, Erhard, Florian, Brinkmann, Melanie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263000/
https://www.ncbi.nlm.nih.gov/pubmed/33947766
http://dx.doi.org/10.1128/mBio.02683-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263000/
https://www.ncbi.nlm.nih.gov/pubmed/33947766
http://dx.doi.org/10.1128/mBio.02683-20

Ejemplares similares