Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain

Measles virus (MeV) bearing a single amino acid change in the fusion protein (F)—L454W—was isolated from two patients who died of MeV central nervous system (CNS) infection. This mutation in F confers an advantage over wild-type virus in the CNS, contributing to disease in these patients. Using muri...

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Detalles Bibliográficos
Autores principales: Mathieu, Cyrille, Bovier, Francesca T., Ferren, Marion, Lieberman, Nicole A. P., Predella, Camilla, Lalande, Alexandre, Peddu, Vikas, Lin, Michelle J., Addetia, Amin, Patel, Achchhe, Outlaw, Victor, Corneo, Barbara, Dorrello, N. Valerio, Briese, Thomas, Hardie, Diana, Horvat, Branka, Moscona, Anne, Greninger, Alexander L., Porotto, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263006/
https://www.ncbi.nlm.nih.gov/pubmed/34061592
http://dx.doi.org/10.1128/mBio.00799-21

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