An Autopsy Case of Primary Biliary Cholangitis with Histological Submassive Hepatic Necrosis Caused by Acute Hepatitis E Virus Infection

A 59-year-old woman who had been diagnosed with cirrhotic primary biliary cholangitis (PBC) 5 years earlier was admitted for severe jaundice (total bilirubin: 30.1 mg/dL). We suspected that her cirrhotic PBC had deteriorated acutely for some reason. Her general condition deteriorated quickly, and sh...

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Detalles Bibliográficos
Autores principales: Koyama, Mizuki, Yamazaki, Tomoo, Joshita, Satoru, Ito, Akihiro, Ono, Kazuyuki, Watanabe, Takayuki, Yamashita, Yuki, Sugiura, Ayumi, Kobayashi, Mikiko, Sato, Yoshinori, Takahashi, Masaharu, Okamoto, Hiroaki, Umemura, Takeji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263169/
https://www.ncbi.nlm.nih.gov/pubmed/33518570
http://dx.doi.org/10.2169/internalmedicine.6337-20
Descripción
Sumario:A 59-year-old woman who had been diagnosed with cirrhotic primary biliary cholangitis (PBC) 5 years earlier was admitted for severe jaundice (total bilirubin: 30.1 mg/dL). We suspected that her cirrhotic PBC had deteriorated acutely for some reason. Her general condition deteriorated quickly, and she passed away on day 18 of admission. Hepatitis E virus (HEV)-IgA antibodies were positive, and Genotype 3b HEV involvement was confirmed from a blood sample taken on admission. Histopathological findings revealed cirrhosis and submassive loss and necrosis of hepatocytes. Clinicians should consider the possibility of acute HEV infection as a trigger for acute PBC exacerbation.

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