Rapidly Progressive Kidney Failure Associated with Perirenal Capsular Lesion Due to IgG4-Related Disease

A 71-year-old Japanese man with progressive kidney failure was referred to our hospital. Laboratory tests showed elevated IgG4 levels. Contrast-enhanced computed tomography (CT) revealed soft tissue surrounding the left kidney and right atrophic kidney. A histopathological examination revealed infla...

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Autores principales: Endo, Nobuhide, Shimizu, Hitomi, Tanaka, Tomoki, Nakase, Yukiko, Kawazoe, Tomohiro, Watanabe, Tomoharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263170/
https://www.ncbi.nlm.nih.gov/pubmed/33456038
http://dx.doi.org/10.2169/internalmedicine.6232-20
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author Endo, Nobuhide
Shimizu, Hitomi
Tanaka, Tomoki
Nakase, Yukiko
Kawazoe, Tomohiro
Watanabe, Tomoharu
author_facet Endo, Nobuhide
Shimizu, Hitomi
Tanaka, Tomoki
Nakase, Yukiko
Kawazoe, Tomohiro
Watanabe, Tomoharu
author_sort Endo, Nobuhide
collection PubMed
description A 71-year-old Japanese man with progressive kidney failure was referred to our hospital. Laboratory tests showed elevated IgG4 levels. Contrast-enhanced computed tomography (CT) revealed soft tissue surrounding the left kidney and right atrophic kidney. A histopathological examination revealed inflammation and fibrosis with rich IgG4-positive cells in the thickened kidney capsule, but not in the kidney parenchyma. Poor enhancement in the left kidney on contrast-enhanced CT and wrinkling of glomerular capillaries in pathological tissues were also observed. These findings indicated IgG4-related perirenal lesions leading to low renal perfusion and kidney failure. The perirenal lesions and kidney failure were improved by corticosteroid therapy.
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spelling pubmed-82631702021-07-12 Rapidly Progressive Kidney Failure Associated with Perirenal Capsular Lesion Due to IgG4-Related Disease Endo, Nobuhide Shimizu, Hitomi Tanaka, Tomoki Nakase, Yukiko Kawazoe, Tomohiro Watanabe, Tomoharu Intern Med Case Report A 71-year-old Japanese man with progressive kidney failure was referred to our hospital. Laboratory tests showed elevated IgG4 levels. Contrast-enhanced computed tomography (CT) revealed soft tissue surrounding the left kidney and right atrophic kidney. A histopathological examination revealed inflammation and fibrosis with rich IgG4-positive cells in the thickened kidney capsule, but not in the kidney parenchyma. Poor enhancement in the left kidney on contrast-enhanced CT and wrinkling of glomerular capillaries in pathological tissues were also observed. These findings indicated IgG4-related perirenal lesions leading to low renal perfusion and kidney failure. The perirenal lesions and kidney failure were improved by corticosteroid therapy. The Japanese Society of Internal Medicine 2021-01-15 2021-06-15 /pmc/articles/PMC8263170/ /pubmed/33456038 http://dx.doi.org/10.2169/internalmedicine.6232-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Endo, Nobuhide
Shimizu, Hitomi
Tanaka, Tomoki
Nakase, Yukiko
Kawazoe, Tomohiro
Watanabe, Tomoharu
Rapidly Progressive Kidney Failure Associated with Perirenal Capsular Lesion Due to IgG4-Related Disease
title Rapidly Progressive Kidney Failure Associated with Perirenal Capsular Lesion Due to IgG4-Related Disease
title_full Rapidly Progressive Kidney Failure Associated with Perirenal Capsular Lesion Due to IgG4-Related Disease
title_fullStr Rapidly Progressive Kidney Failure Associated with Perirenal Capsular Lesion Due to IgG4-Related Disease
title_full_unstemmed Rapidly Progressive Kidney Failure Associated with Perirenal Capsular Lesion Due to IgG4-Related Disease
title_short Rapidly Progressive Kidney Failure Associated with Perirenal Capsular Lesion Due to IgG4-Related Disease
title_sort rapidly progressive kidney failure associated with perirenal capsular lesion due to igg4-related disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263170/
https://www.ncbi.nlm.nih.gov/pubmed/33456038
http://dx.doi.org/10.2169/internalmedicine.6232-20
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