HGG-42. PEDIATRIC H3K27M MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) SHOWS ROBUST RESPONSE TO IMIPRIDONE BASED COMBINATION THERAPY

ONC201 is a first-in-class small molecule imipridone therapy, which is known to selectively induce apoptosis of cancer cells independent of p53. This novel chemotherapeutic, as well as its analogs ONC206 and ONC212, has been shown to have potent preclinical efficacy against H3K27M mutant diffuse int...

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Detalles Bibliográficos
Autores principales: Borsuk, Robyn, Zhou, Lanlan, Chang, Wen-i, Zhang, Yiqun, Prabhu, Varun, Allen, Joshua, Tapinos, Nikos, Lulla, Rishi, El-Deiry, Wafik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
High Grade Gliomas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263206/
http://dx.doi.org/10.1093/neuonc/noab090.106

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