NFAT transcription factors are essential and redundant actors for leukemia initiating potential in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy with few available targeted therapies. We previously reported that the phosphatase calcineurin (Cn) is required for LIC (leukemia Initiating Capacity) potential of T-ALL pointing to Cn as an interesting therapeutic target. Calci...

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Detalles Bibliográficos
Autores principales: Catherinet, Claire, Passaro, Diana, Gachet, Stéphanie, Medyouf, Hind, Reynaud, Anne, Lasgi, Charlène, Ghysdael, Jacques, Tran Quang, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263285/
https://www.ncbi.nlm.nih.gov/pubmed/34234374
http://dx.doi.org/10.1371/journal.pone.0254184

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