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Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years

Numbers of Hematopoietic cell transplantation (HCT) in Europe and collaborating countries continues to rise with 48,512 HCT in 43,581 patients, comprising of 19,798 (41%) allogeneic and 28,714 (59%) autologous, reported by 700 centers in 51 countries during 2019. Main indications were myeloid malign...

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Autores principales: Passweg, Jakob R., Baldomero, Helen, Chabannon, Christian, Basak, Grzegorz W., de la Cámara, Rafael, Corbacioglu, Selim, Dolstra, Harry, Duarte, Rafael, Glass, Bertram, Greco, Raffaella, Lankester, Arjan C., Mohty, Mohamad, Peffault de Latour, Régis, Snowden, John A., Yakoub-Agha, Ibrahim, Kröger, Nicolaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263343/
https://www.ncbi.nlm.nih.gov/pubmed/33623153
http://dx.doi.org/10.1038/s41409-021-01227-8
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author Passweg, Jakob R.
Baldomero, Helen
Chabannon, Christian
Basak, Grzegorz W.
de la Cámara, Rafael
Corbacioglu, Selim
Dolstra, Harry
Duarte, Rafael
Glass, Bertram
Greco, Raffaella
Lankester, Arjan C.
Mohty, Mohamad
Peffault de Latour, Régis
Snowden, John A.
Yakoub-Agha, Ibrahim
Kröger, Nicolaus
author_facet Passweg, Jakob R.
Baldomero, Helen
Chabannon, Christian
Basak, Grzegorz W.
de la Cámara, Rafael
Corbacioglu, Selim
Dolstra, Harry
Duarte, Rafael
Glass, Bertram
Greco, Raffaella
Lankester, Arjan C.
Mohty, Mohamad
Peffault de Latour, Régis
Snowden, John A.
Yakoub-Agha, Ibrahim
Kröger, Nicolaus
author_sort Passweg, Jakob R.
collection PubMed
description Numbers of Hematopoietic cell transplantation (HCT) in Europe and collaborating countries continues to rise with 48,512 HCT in 43,581 patients, comprising of 19,798 (41%) allogeneic and 28,714 (59%) autologous, reported by 700 centers in 51 countries during 2019. Main indications were myeloid malignancies 10,764 (25%), lymphoid malignancies 27,895 (64%), and nonmalignant disorders 3173 (7%). A marked growth in CAR-T cellular therapies from 151 in 2017 to 1134 patients in 2019 is observed. This year’s analyses focus on changes over 30 years. Since the first survey in 1990 where 143 centers reported 4234 HCT, the number has increased to 700 centers and 48,512 HCT. Transplants were reported in 20 countries in 1990, and 51, 30 years later. More than 800,000 HCT in 715,000 patients were reported overall. Next to the massive expansion of HCT technology, most notable developments include the success of unrelated donor and haploidentical HCT, an increase followed by decrease in the number of cord blood transplants, use of reduced intensity HCT in older patients, and the phenomenal rise in cellular therapy. This annual report of the European Society for Blood and Marrow Transplantation (EBMT) reflects current activity and highlights important trends vital for health care planning.
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spelling pubmed-82633432021-07-23 Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years Passweg, Jakob R. Baldomero, Helen Chabannon, Christian Basak, Grzegorz W. de la Cámara, Rafael Corbacioglu, Selim Dolstra, Harry Duarte, Rafael Glass, Bertram Greco, Raffaella Lankester, Arjan C. Mohty, Mohamad Peffault de Latour, Régis Snowden, John A. Yakoub-Agha, Ibrahim Kröger, Nicolaus Bone Marrow Transplant Article Numbers of Hematopoietic cell transplantation (HCT) in Europe and collaborating countries continues to rise with 48,512 HCT in 43,581 patients, comprising of 19,798 (41%) allogeneic and 28,714 (59%) autologous, reported by 700 centers in 51 countries during 2019. Main indications were myeloid malignancies 10,764 (25%), lymphoid malignancies 27,895 (64%), and nonmalignant disorders 3173 (7%). A marked growth in CAR-T cellular therapies from 151 in 2017 to 1134 patients in 2019 is observed. This year’s analyses focus on changes over 30 years. Since the first survey in 1990 where 143 centers reported 4234 HCT, the number has increased to 700 centers and 48,512 HCT. Transplants were reported in 20 countries in 1990, and 51, 30 years later. More than 800,000 HCT in 715,000 patients were reported overall. Next to the massive expansion of HCT technology, most notable developments include the success of unrelated donor and haploidentical HCT, an increase followed by decrease in the number of cord blood transplants, use of reduced intensity HCT in older patients, and the phenomenal rise in cellular therapy. This annual report of the European Society for Blood and Marrow Transplantation (EBMT) reflects current activity and highlights important trends vital for health care planning. Nature Publishing Group UK 2021-02-23 2021 /pmc/articles/PMC8263343/ /pubmed/33623153 http://dx.doi.org/10.1038/s41409-021-01227-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Passweg, Jakob R.
Baldomero, Helen
Chabannon, Christian
Basak, Grzegorz W.
de la Cámara, Rafael
Corbacioglu, Selim
Dolstra, Harry
Duarte, Rafael
Glass, Bertram
Greco, Raffaella
Lankester, Arjan C.
Mohty, Mohamad
Peffault de Latour, Régis
Snowden, John A.
Yakoub-Agha, Ibrahim
Kröger, Nicolaus
Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years
title Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years
title_full Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years
title_fullStr Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years
title_full_unstemmed Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years
title_short Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years
title_sort hematopoietic cell transplantation and cellular therapy survey of the ebmt: monitoring of activities and trends over 30 years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263343/
https://www.ncbi.nlm.nih.gov/pubmed/33623153
http://dx.doi.org/10.1038/s41409-021-01227-8
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