Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Interplay between EBV infection and acquired genetic alterations during nasopharyngeal carcinoma (NPC) development remains vague. Here we report a comprehensive genomic analysis of 70 NPCs, combining whole-genome sequencing (WGS) of microdissected tumor cells with EBV oncogene expression to reveal m...

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Detalles Bibliográficos
Autores principales: Bruce, Jeff P., To, Ka-Fai, Lui, Vivian W. Y., Chung, Grace T. Y., Chan, Yuk-Yu, Tsang, Chi Man, Yip, Kevin Y., Ma, Brigette B. Y., Woo, John K. S., Hui, Edwin P., Mak, Michael K. F., Lee, Sau-Dan, Chow, Chit, Velapasamy, Sharmila, Or, Yvonne Y. Y., Siu, Pui Kei, El Ghamrasni, Samah, Prokopec, Stephenie, Wu, Man, Kwan, Johnny S. H., Liu, Yuchen, Chan, Jason Y. K., van Hasselt, C. Andrew, Young, Lawrence S., Dawson, Christopher W., Paterson, Ian C., Yap, Lee-Fah, Tsao, Sai-Wah, Liu, Fei-Fei, Chan, Anthony T. C., Pugh, Trevor J., Lo, Kwok-Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263564/
https://www.ncbi.nlm.nih.gov/pubmed/34234122
http://dx.doi.org/10.1038/s41467-021-24348-6

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