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An engineered tetra-valent antibody fully activates the Tie2 receptor with comparable potency to its natural ligand angiopoietin-1

Activation of the tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2) receptor by angiopoietin-1 (Ang1) is critical for vascular stabilization: it promotes survival signal transduction via auto-phosphorylation and reduces vascular permeability by strengthening tight junction...

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Detalles Bibliográficos
Autores principales:	Koya, Yukari, Nara, Hiromi, Yagi, Shigenori, Ueno, Chihoko, Kamohara, Masazumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263585/ https://www.ncbi.nlm.nih.gov/pubmed/34234265 http://dx.doi.org/10.1038/s41598-021-93660-4

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