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Translocation of vaginal microbiota is involved in impairment and protection of uterine health
The vaginal and uterine microbiota play important roles in the health of the female reproductive system. However, the interactions among the microbes in these two niches and their effects on uterine health remain unclear. Here we profile the vaginal and uterine microbial samples of 145 women, and co...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263591/ https://www.ncbi.nlm.nih.gov/pubmed/34234149 http://dx.doi.org/10.1038/s41467-021-24516-8 |
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author | Wang, Jinfeng Li, Zhanzhan Ma, Xiuling Du, Lifeng Jia, Zhen Cui, Xue Yu, Liqun Yang, Jing Xiao, Liwen Zhang, Bing Fan, Huimin Zhao, Fangqing |
author_facet | Wang, Jinfeng Li, Zhanzhan Ma, Xiuling Du, Lifeng Jia, Zhen Cui, Xue Yu, Liqun Yang, Jing Xiao, Liwen Zhang, Bing Fan, Huimin Zhao, Fangqing |
author_sort | Wang, Jinfeng |
collection | PubMed |
description | The vaginal and uterine microbiota play important roles in the health of the female reproductive system. However, the interactions among the microbes in these two niches and their effects on uterine health remain unclear. Here we profile the vaginal and uterine microbial samples of 145 women, and combine with deep mining of public data and animal experiments to characterize the microbial translocation in the female reproductive tract and its role in modulating uterine health. Synchronous variation and increasing convergence of the uterine and vaginal microbiome with advancing age are shown. We also find that transplanting certain strains of vaginal bacteria into the vagina of rats induces or reduces endometritis-like symptoms, and verify the damaging or protective effects of certain vaginal bacteria on endometrium. This study clarifies the interdependent relationship of vaginal bacterial translocation with uterine microecology and endometrial health, which will undoubtedly increase our understanding of female reproductive health. |
format | Online Article Text |
id | pubmed-8263591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82635912021-07-23 Translocation of vaginal microbiota is involved in impairment and protection of uterine health Wang, Jinfeng Li, Zhanzhan Ma, Xiuling Du, Lifeng Jia, Zhen Cui, Xue Yu, Liqun Yang, Jing Xiao, Liwen Zhang, Bing Fan, Huimin Zhao, Fangqing Nat Commun Article The vaginal and uterine microbiota play important roles in the health of the female reproductive system. However, the interactions among the microbes in these two niches and their effects on uterine health remain unclear. Here we profile the vaginal and uterine microbial samples of 145 women, and combine with deep mining of public data and animal experiments to characterize the microbial translocation in the female reproductive tract and its role in modulating uterine health. Synchronous variation and increasing convergence of the uterine and vaginal microbiome with advancing age are shown. We also find that transplanting certain strains of vaginal bacteria into the vagina of rats induces or reduces endometritis-like symptoms, and verify the damaging or protective effects of certain vaginal bacteria on endometrium. This study clarifies the interdependent relationship of vaginal bacterial translocation with uterine microecology and endometrial health, which will undoubtedly increase our understanding of female reproductive health. Nature Publishing Group UK 2021-07-07 /pmc/articles/PMC8263591/ /pubmed/34234149 http://dx.doi.org/10.1038/s41467-021-24516-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Wang, Jinfeng Li, Zhanzhan Ma, Xiuling Du, Lifeng Jia, Zhen Cui, Xue Yu, Liqun Yang, Jing Xiao, Liwen Zhang, Bing Fan, Huimin Zhao, Fangqing Translocation of vaginal microbiota is involved in impairment and protection of uterine health |
title | Translocation of vaginal microbiota is involved in impairment and protection of uterine health |
title_full | Translocation of vaginal microbiota is involved in impairment and protection of uterine health |
title_fullStr | Translocation of vaginal microbiota is involved in impairment and protection of uterine health |
title_full_unstemmed | Translocation of vaginal microbiota is involved in impairment and protection of uterine health |
title_short | Translocation of vaginal microbiota is involved in impairment and protection of uterine health |
title_sort | translocation of vaginal microbiota is involved in impairment and protection of uterine health |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263591/ https://www.ncbi.nlm.nih.gov/pubmed/34234149 http://dx.doi.org/10.1038/s41467-021-24516-8 |
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