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The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo

Reports of P. vivax infections among Duffy-negative hosts have accumulated throughout sub-Saharan Africa. Despite this growing body of evidence, no nationally representative epidemiological surveys of P. vivax in sub-Saharan Africa have been performed. To overcome this gap in knowledge, we screened...

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Autores principales: Brazeau, Nicholas F., Mitchell, Cedar L., Morgan, Andrew P., Deutsch-Feldman, Molly, Watson, Oliver John, Thwai, Kyaw L., Gelabert, Pere, van Dorp, Lucy, Keeler, Corinna Y., Waltmann, Andreea, Emch, Michael, Gartner, Valerie, Redelings, Ben, Wray, Gregory A., Mwandagalirwa, Melchior K., Tshefu, Antoinette K., Likwela, Joris L., Edwards, Jessie K., Verity, Robert, Parr, Jonathan B., Meshnick, Steven R., Juliano, Jonathan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263614/
https://www.ncbi.nlm.nih.gov/pubmed/34234124
http://dx.doi.org/10.1038/s41467-021-24216-3
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author Brazeau, Nicholas F.
Mitchell, Cedar L.
Morgan, Andrew P.
Deutsch-Feldman, Molly
Watson, Oliver John
Thwai, Kyaw L.
Gelabert, Pere
van Dorp, Lucy
Keeler, Corinna Y.
Waltmann, Andreea
Emch, Michael
Gartner, Valerie
Redelings, Ben
Wray, Gregory A.
Mwandagalirwa, Melchior K.
Tshefu, Antoinette K.
Likwela, Joris L.
Edwards, Jessie K.
Verity, Robert
Parr, Jonathan B.
Meshnick, Steven R.
Juliano, Jonathan J.
author_facet Brazeau, Nicholas F.
Mitchell, Cedar L.
Morgan, Andrew P.
Deutsch-Feldman, Molly
Watson, Oliver John
Thwai, Kyaw L.
Gelabert, Pere
van Dorp, Lucy
Keeler, Corinna Y.
Waltmann, Andreea
Emch, Michael
Gartner, Valerie
Redelings, Ben
Wray, Gregory A.
Mwandagalirwa, Melchior K.
Tshefu, Antoinette K.
Likwela, Joris L.
Edwards, Jessie K.
Verity, Robert
Parr, Jonathan B.
Meshnick, Steven R.
Juliano, Jonathan J.
author_sort Brazeau, Nicholas F.
collection PubMed
description Reports of P. vivax infections among Duffy-negative hosts have accumulated throughout sub-Saharan Africa. Despite this growing body of evidence, no nationally representative epidemiological surveys of P. vivax in sub-Saharan Africa have been performed. To overcome this gap in knowledge, we screened over 17,000 adults in the Democratic Republic of the Congo (DRC) for P. vivax using samples from the 2013-2014 Demographic Health Survey. Overall, we found a 2.97% (95% CI: 2.28%, 3.65%) prevalence of P. vivax infections across the DRC. Infections were associated with few risk-factors and demonstrated a relatively flat distribution of prevalence across space with focal regions of relatively higher prevalence in the north and northeast. Mitochondrial genomes suggested that DRC P. vivax were distinct from circulating non-human ape strains and an ancestral European P. vivax strain, and instead may be part of a separate contemporary clade. Our findings suggest P. vivax is diffusely spread across the DRC at a low prevalence, which may be associated with long-term carriage of low parasitemia, frequent relapses, or a general pool of infections with limited forward propagation.
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spelling pubmed-82636142021-07-23 The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo Brazeau, Nicholas F. Mitchell, Cedar L. Morgan, Andrew P. Deutsch-Feldman, Molly Watson, Oliver John Thwai, Kyaw L. Gelabert, Pere van Dorp, Lucy Keeler, Corinna Y. Waltmann, Andreea Emch, Michael Gartner, Valerie Redelings, Ben Wray, Gregory A. Mwandagalirwa, Melchior K. Tshefu, Antoinette K. Likwela, Joris L. Edwards, Jessie K. Verity, Robert Parr, Jonathan B. Meshnick, Steven R. Juliano, Jonathan J. Nat Commun Article Reports of P. vivax infections among Duffy-negative hosts have accumulated throughout sub-Saharan Africa. Despite this growing body of evidence, no nationally representative epidemiological surveys of P. vivax in sub-Saharan Africa have been performed. To overcome this gap in knowledge, we screened over 17,000 adults in the Democratic Republic of the Congo (DRC) for P. vivax using samples from the 2013-2014 Demographic Health Survey. Overall, we found a 2.97% (95% CI: 2.28%, 3.65%) prevalence of P. vivax infections across the DRC. Infections were associated with few risk-factors and demonstrated a relatively flat distribution of prevalence across space with focal regions of relatively higher prevalence in the north and northeast. Mitochondrial genomes suggested that DRC P. vivax were distinct from circulating non-human ape strains and an ancestral European P. vivax strain, and instead may be part of a separate contemporary clade. Our findings suggest P. vivax is diffusely spread across the DRC at a low prevalence, which may be associated with long-term carriage of low parasitemia, frequent relapses, or a general pool of infections with limited forward propagation. Nature Publishing Group UK 2021-07-07 /pmc/articles/PMC8263614/ /pubmed/34234124 http://dx.doi.org/10.1038/s41467-021-24216-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Brazeau, Nicholas F.
Mitchell, Cedar L.
Morgan, Andrew P.
Deutsch-Feldman, Molly
Watson, Oliver John
Thwai, Kyaw L.
Gelabert, Pere
van Dorp, Lucy
Keeler, Corinna Y.
Waltmann, Andreea
Emch, Michael
Gartner, Valerie
Redelings, Ben
Wray, Gregory A.
Mwandagalirwa, Melchior K.
Tshefu, Antoinette K.
Likwela, Joris L.
Edwards, Jessie K.
Verity, Robert
Parr, Jonathan B.
Meshnick, Steven R.
Juliano, Jonathan J.
The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo
title The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo
title_full The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo
title_fullStr The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo
title_full_unstemmed The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo
title_short The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo
title_sort epidemiology of plasmodium vivax among adults in the democratic republic of the congo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263614/
https://www.ncbi.nlm.nih.gov/pubmed/34234124
http://dx.doi.org/10.1038/s41467-021-24216-3
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