A MYBL2 complex for RRM2 transactivation and the synthetic effect of MYBL2 knockdown with WEE1 inhibition against colorectal cancer

Ribonucleotide reductase (RR) is a unique enzyme for the reduction of NDPs to dNDPs, the building blocks for DNA synthesis and thus essential for cell proliferation. Pan-cancer profiling studies showed that RRM2, the small subunit M2 of RR, is abnormally overexpressed in multiple types of cancers; h...

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Detalles Bibliográficos
Autores principales: Liu, Qian, Guo, Lijuan, Qi, Hongyan, Lou, Meng, Wang, Rui, Hai, Boning, Xu, Kailun, Zhu, Lijun, Ding, Yongfeng, Li, Chen, Xie, Lingdan, Shen, Jing, Xiang, Xueping, Shao, Jimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263627/
https://www.ncbi.nlm.nih.gov/pubmed/34234118
http://dx.doi.org/10.1038/s41419-021-03969-1

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