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Reversal of senescence-associated beta-galactosidase expression during in vitro three-dimensional tissue-engineering of human chondrocytes in a polymer scaffold

Regenerative medicine applications require cells that are not inflicted with senescence after in vitro culture for an optimal in vivo outcome. Methods to overcome replicative senescence include genomic modifications which have their own disadvantages. We have evaluated a three-dimensional (3D) therm...

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Detalles Bibliográficos
Autores principales:	Katoh, Shojiro, Fujimaru, Atsuki, Iwasaki, Masaru, Yoshioka, Hiroshi, Senthilkumar, Rajappa, Preethy, Senthilkumar, Abraham, Samuel J. K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263703/ https://www.ncbi.nlm.nih.gov/pubmed/34234261 http://dx.doi.org/10.1038/s41598-021-93607-9

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