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Corneal pachymetry by AS-OCT after Descemet’s membrane endothelial keratoplasty
Corneal thickness (pachymetry) maps can be used to monitor restoration of corneal endothelial function, for example after Descemet’s membrane endothelial keratoplasty (DMEK). Automated delineation of the corneal interfaces in anterior segment optical coherence tomography (AS-OCT) can be challenging...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263705/ https://www.ncbi.nlm.nih.gov/pubmed/34234179 http://dx.doi.org/10.1038/s41598-021-93186-9 |
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author | Heslinga, Friso G. Lucassen, Ruben T. van den Berg, Myrthe A. van der Hoek, Luuk Pluim, Josien P. W. Cabrerizo, Javier Alberti, Mark Veta, Mitko |
author_facet | Heslinga, Friso G. Lucassen, Ruben T. van den Berg, Myrthe A. van der Hoek, Luuk Pluim, Josien P. W. Cabrerizo, Javier Alberti, Mark Veta, Mitko |
author_sort | Heslinga, Friso G. |
collection | PubMed |
description | Corneal thickness (pachymetry) maps can be used to monitor restoration of corneal endothelial function, for example after Descemet’s membrane endothelial keratoplasty (DMEK). Automated delineation of the corneal interfaces in anterior segment optical coherence tomography (AS-OCT) can be challenging for corneas that are irregularly shaped due to pathology, or as a consequence of surgery, leading to incorrect thickness measurements. In this research, deep learning is used to automatically delineate the corneal interfaces and measure corneal thickness with high accuracy in post-DMEK AS-OCT B-scans. Three different deep learning strategies were developed based on 960 B-scans from 50 patients. On an independent test set of 320 B-scans, corneal thickness could be measured with an error of 13.98 to 15.50 μm for the central 9 mm range, which is less than 3% of the average corneal thickness. The accurate thickness measurements were used to construct detailed pachymetry maps. Moreover, follow-up scans could be registered based on anatomical landmarks to obtain differential pachymetry maps. These maps may enable a more comprehensive understanding of the restoration of the endothelial function after DMEK, where thickness often varies throughout different regions of the cornea, and subsequently contribute to a standardized postoperative regime. |
format | Online Article Text |
id | pubmed-8263705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82637052021-07-09 Corneal pachymetry by AS-OCT after Descemet’s membrane endothelial keratoplasty Heslinga, Friso G. Lucassen, Ruben T. van den Berg, Myrthe A. van der Hoek, Luuk Pluim, Josien P. W. Cabrerizo, Javier Alberti, Mark Veta, Mitko Sci Rep Article Corneal thickness (pachymetry) maps can be used to monitor restoration of corneal endothelial function, for example after Descemet’s membrane endothelial keratoplasty (DMEK). Automated delineation of the corneal interfaces in anterior segment optical coherence tomography (AS-OCT) can be challenging for corneas that are irregularly shaped due to pathology, or as a consequence of surgery, leading to incorrect thickness measurements. In this research, deep learning is used to automatically delineate the corneal interfaces and measure corneal thickness with high accuracy in post-DMEK AS-OCT B-scans. Three different deep learning strategies were developed based on 960 B-scans from 50 patients. On an independent test set of 320 B-scans, corneal thickness could be measured with an error of 13.98 to 15.50 μm for the central 9 mm range, which is less than 3% of the average corneal thickness. The accurate thickness measurements were used to construct detailed pachymetry maps. Moreover, follow-up scans could be registered based on anatomical landmarks to obtain differential pachymetry maps. These maps may enable a more comprehensive understanding of the restoration of the endothelial function after DMEK, where thickness often varies throughout different regions of the cornea, and subsequently contribute to a standardized postoperative regime. Nature Publishing Group UK 2021-07-07 /pmc/articles/PMC8263705/ /pubmed/34234179 http://dx.doi.org/10.1038/s41598-021-93186-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Heslinga, Friso G. Lucassen, Ruben T. van den Berg, Myrthe A. van der Hoek, Luuk Pluim, Josien P. W. Cabrerizo, Javier Alberti, Mark Veta, Mitko Corneal pachymetry by AS-OCT after Descemet’s membrane endothelial keratoplasty |
title | Corneal pachymetry by AS-OCT after Descemet’s membrane endothelial keratoplasty |
title_full | Corneal pachymetry by AS-OCT after Descemet’s membrane endothelial keratoplasty |
title_fullStr | Corneal pachymetry by AS-OCT after Descemet’s membrane endothelial keratoplasty |
title_full_unstemmed | Corneal pachymetry by AS-OCT after Descemet’s membrane endothelial keratoplasty |
title_short | Corneal pachymetry by AS-OCT after Descemet’s membrane endothelial keratoplasty |
title_sort | corneal pachymetry by as-oct after descemet’s membrane endothelial keratoplasty |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263705/ https://www.ncbi.nlm.nih.gov/pubmed/34234179 http://dx.doi.org/10.1038/s41598-021-93186-9 |
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