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Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation

As a promising future treatment for stroke rehabilitation, researchers have developed direct brain stimulation to manipulate the neural excitability. However, there has been less interest in energy consumption and unexpected side effect caused by electrical stimulation to bring functional recovery f...

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Autores principales: Kim, Kyungsoo, Yoo, Seung-Jun, Kim, So Yeon, Lee, Taeju, Lim, Sung-Ho, Jang, Jae-Eun, Je, Minkyu, Moon, Cheil, Choi, Ji-Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263745/
https://www.ncbi.nlm.nih.gov/pubmed/34234199
http://dx.doi.org/10.1038/s41598-021-93354-x
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author Kim, Kyungsoo
Yoo, Seung-Jun
Kim, So Yeon
Lee, Taeju
Lim, Sung-Ho
Jang, Jae-Eun
Je, Minkyu
Moon, Cheil
Choi, Ji-Woong
author_facet Kim, Kyungsoo
Yoo, Seung-Jun
Kim, So Yeon
Lee, Taeju
Lim, Sung-Ho
Jang, Jae-Eun
Je, Minkyu
Moon, Cheil
Choi, Ji-Woong
author_sort Kim, Kyungsoo
collection PubMed
description As a promising future treatment for stroke rehabilitation, researchers have developed direct brain stimulation to manipulate the neural excitability. However, there has been less interest in energy consumption and unexpected side effect caused by electrical stimulation to bring functional recovery for stroke rehabilitation. In this study, we propose an engineering approach with subthreshold electrical stimulation (STES) to bring functional recovery. Here, we show a low level of electrical stimulation boosted causal excitation in connected neurons and strengthened the synaptic weight in a simulation study. We found that STES with motor training enhanced functional recovery after stroke in vivo. STES was shown to induce neural reconstruction, indicated by higher neurite expression in the stimulated regions and correlated changes in behavioral performance and neural spike firing pattern during the rehabilitation process. This will reduce the energy consumption of implantable devices and the side effects caused by stimulating unwanted brain regions.
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spelling pubmed-82637452021-07-09 Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation Kim, Kyungsoo Yoo, Seung-Jun Kim, So Yeon Lee, Taeju Lim, Sung-Ho Jang, Jae-Eun Je, Minkyu Moon, Cheil Choi, Ji-Woong Sci Rep Article As a promising future treatment for stroke rehabilitation, researchers have developed direct brain stimulation to manipulate the neural excitability. However, there has been less interest in energy consumption and unexpected side effect caused by electrical stimulation to bring functional recovery for stroke rehabilitation. In this study, we propose an engineering approach with subthreshold electrical stimulation (STES) to bring functional recovery. Here, we show a low level of electrical stimulation boosted causal excitation in connected neurons and strengthened the synaptic weight in a simulation study. We found that STES with motor training enhanced functional recovery after stroke in vivo. STES was shown to induce neural reconstruction, indicated by higher neurite expression in the stimulated regions and correlated changes in behavioral performance and neural spike firing pattern during the rehabilitation process. This will reduce the energy consumption of implantable devices and the side effects caused by stimulating unwanted brain regions. Nature Publishing Group UK 2021-07-07 /pmc/articles/PMC8263745/ /pubmed/34234199 http://dx.doi.org/10.1038/s41598-021-93354-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kim, Kyungsoo
Yoo, Seung-Jun
Kim, So Yeon
Lee, Taeju
Lim, Sung-Ho
Jang, Jae-Eun
Je, Minkyu
Moon, Cheil
Choi, Ji-Woong
Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
title Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
title_full Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
title_fullStr Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
title_full_unstemmed Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
title_short Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
title_sort subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263745/
https://www.ncbi.nlm.nih.gov/pubmed/34234199
http://dx.doi.org/10.1038/s41598-021-93354-x
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