NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir

Nucleobase and nucleoside analogs (NNA) are widely used as anti-viral and anti-cancer agents, and NNA phosphorylation is essential for the activity of this class of drugs. Recently, diphosphatase NUDT15 was linked to thiopurine metabolism with NUDT15 polymorphism associated with drug toxicity in pat...

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Detalles Bibliográficos
Autores principales: Nishii, Rina, Mizuno, Takanori, Rehling, Daniel, Smith, Colton, Clark, Brandi L., Zhao, Xujie, Brown, Scott A., Smart, Brandon, Moriyama, Takaya, Yamada, Yuji, Ichinohe, Tatsuo, Onizuka, Makoto, Atsuta, Yoshiko, Yang, Lei, Yang, Wenjian, Thomas, Paul G., Stenmark, Pål, Kato, Motohiro, Yang, Jun J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263746/
https://www.ncbi.nlm.nih.gov/pubmed/34234136
http://dx.doi.org/10.1038/s41467-021-24509-7

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