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Current research advances in microRNA-mediated regulation of Krüppel-like factor 4 in cancer: a narrative review
OBJECTIVE: The purpose of this study was to investigate the miRNAs and related mechanisms that regulates KLF4 in different cancers. Furthermore, we summarized the potential targets of miRNAs regulating the KLF4 pathway in cancer research. BACKGROUND: MiRNAs are single-stranded, endogenous non-coding...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263881/ https://www.ncbi.nlm.nih.gov/pubmed/34350263 http://dx.doi.org/10.21037/atm-21-2347 |
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author | Yang, Xi Chen, Cheng Li, Li Xiao, Tian Zou, Yong-Dong Zheng, Duo |
author_facet | Yang, Xi Chen, Cheng Li, Li Xiao, Tian Zou, Yong-Dong Zheng, Duo |
author_sort | Yang, Xi |
collection | PubMed |
description | OBJECTIVE: The purpose of this study was to investigate the miRNAs and related mechanisms that regulates KLF4 in different cancers. Furthermore, we summarized the potential targets of miRNAs regulating the KLF4 pathway in cancer research. BACKGROUND: MiRNAs are single-stranded, endogenous non-coding small RNAs, some of which are related to human cancers. miRNAs carry out post-transcriptional gene regulation through translation inhibition and degradation of target messenger RNAs (mRNAs) via complementarily pairing with their 3’ untranslated regions. KLF4 is an important transcription factor with complex involvement in cancer. Increasing evidence shows that miRNAs are dysregulated in cancer and can regulate cancer-related signaling pathways, thereby affecting tumor progression. METHODS: Systematic scientific literature searches were undertaken on PubMed using the following terms: “miRNAs and KLF4”, “KLF4 and cancer”, “miRNAs and cancer”, and “miRNAs, KLF4 and cancer”. Relevant papers were retrieved and further results were found by reviewing related papers and the references of the retrieved papers. We then conducted a narrative overview of the literature to summarize the results of the papers. CONCLUSIONS: The role of KLF4 in cancer varies in a context-dependent manner. KLF4-regulating miRNAs in different tumors include miR-124, miR-9-5p, miR-10b, miR-18a, miR-25-3p, miR-10b, miR-92a, miR-103, miR-155, miR-135b-5p, miR-32-5p, miR-148-3p, miR-152-3p, miR-10b, miR-25, miR-3120-5p, miR-7, miR-1233-3p, miR-10b, miR-145, miR-139-5p, miR-16, miR-152, miR-375, and miR-145. |
format | Online Article Text |
id | pubmed-8263881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-82638812021-08-03 Current research advances in microRNA-mediated regulation of Krüppel-like factor 4 in cancer: a narrative review Yang, Xi Chen, Cheng Li, Li Xiao, Tian Zou, Yong-Dong Zheng, Duo Ann Transl Med Review Article OBJECTIVE: The purpose of this study was to investigate the miRNAs and related mechanisms that regulates KLF4 in different cancers. Furthermore, we summarized the potential targets of miRNAs regulating the KLF4 pathway in cancer research. BACKGROUND: MiRNAs are single-stranded, endogenous non-coding small RNAs, some of which are related to human cancers. miRNAs carry out post-transcriptional gene regulation through translation inhibition and degradation of target messenger RNAs (mRNAs) via complementarily pairing with their 3’ untranslated regions. KLF4 is an important transcription factor with complex involvement in cancer. Increasing evidence shows that miRNAs are dysregulated in cancer and can regulate cancer-related signaling pathways, thereby affecting tumor progression. METHODS: Systematic scientific literature searches were undertaken on PubMed using the following terms: “miRNAs and KLF4”, “KLF4 and cancer”, “miRNAs and cancer”, and “miRNAs, KLF4 and cancer”. Relevant papers were retrieved and further results were found by reviewing related papers and the references of the retrieved papers. We then conducted a narrative overview of the literature to summarize the results of the papers. CONCLUSIONS: The role of KLF4 in cancer varies in a context-dependent manner. KLF4-regulating miRNAs in different tumors include miR-124, miR-9-5p, miR-10b, miR-18a, miR-25-3p, miR-10b, miR-92a, miR-103, miR-155, miR-135b-5p, miR-32-5p, miR-148-3p, miR-152-3p, miR-10b, miR-25, miR-3120-5p, miR-7, miR-1233-3p, miR-10b, miR-145, miR-139-5p, miR-16, miR-152, miR-375, and miR-145. AME Publishing Company 2021-06 /pmc/articles/PMC8263881/ /pubmed/34350263 http://dx.doi.org/10.21037/atm-21-2347 Text en 2021 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Article Yang, Xi Chen, Cheng Li, Li Xiao, Tian Zou, Yong-Dong Zheng, Duo Current research advances in microRNA-mediated regulation of Krüppel-like factor 4 in cancer: a narrative review |
title | Current research advances in microRNA-mediated regulation of Krüppel-like factor 4 in cancer: a narrative review |
title_full | Current research advances in microRNA-mediated regulation of Krüppel-like factor 4 in cancer: a narrative review |
title_fullStr | Current research advances in microRNA-mediated regulation of Krüppel-like factor 4 in cancer: a narrative review |
title_full_unstemmed | Current research advances in microRNA-mediated regulation of Krüppel-like factor 4 in cancer: a narrative review |
title_short | Current research advances in microRNA-mediated regulation of Krüppel-like factor 4 in cancer: a narrative review |
title_sort | current research advances in microrna-mediated regulation of krüppel-like factor 4 in cancer: a narrative review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263881/ https://www.ncbi.nlm.nih.gov/pubmed/34350263 http://dx.doi.org/10.21037/atm-21-2347 |
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