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Autonomic Modulation During Baseline and Recovery Sleep in Adult Sleepwalkers

Sleepwalking has been conceptualized as deregulation between slow-wave sleep and arousal, with its occurrence in predisposed patients increasing following sleep deprivation. Recent evidence showed autonomic changes before arousals and somnambulistic episodes, suggesting that autonomic dysfunctions m...

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Autores principales: Scavone, Geneviève, Baril, Andrée-Ann, Montplaisir, Jacques, Carrier, Julie, Desautels, Alex, Zadra, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263899/
https://www.ncbi.nlm.nih.gov/pubmed/34248823
http://dx.doi.org/10.3389/fneur.2021.680596
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author Scavone, Geneviève
Baril, Andrée-Ann
Montplaisir, Jacques
Carrier, Julie
Desautels, Alex
Zadra, Antonio
author_facet Scavone, Geneviève
Baril, Andrée-Ann
Montplaisir, Jacques
Carrier, Julie
Desautels, Alex
Zadra, Antonio
author_sort Scavone, Geneviève
collection PubMed
description Sleepwalking has been conceptualized as deregulation between slow-wave sleep and arousal, with its occurrence in predisposed patients increasing following sleep deprivation. Recent evidence showed autonomic changes before arousals and somnambulistic episodes, suggesting that autonomic dysfunctions may contribute to the pathophysiology of sleepwalking. We investigated cardiac autonomic modulation during slow-wave sleep in sleepwalkers and controls during normal and recovery sleep following sleep deprivation. Fourteen adult sleepwalkers (5M; 28.1 ± 5.8 years) and 14 sex- and age-matched normal controls were evaluated by video-polysomnography for one baseline night and during recovery sleep following 25 h of sleep deprivation. Autonomic modulation was investigated with heart rate variability during participants' slow-wave sleep in their first and second sleep cycles. 5-min electrocardiographic segments from slow-wave sleep were analyzed to investigate low-frequency (LF) and high-frequency (HF) components of heart rate spectral decomposition. Group (sleepwalkers, controls) X condition (baseline, recovery) ANOVAs were performed to compare LF and HF in absolute and normalized units (nLF and nHF), and LF/HF ratio. When compared to controls, sleepwalkers' recovery slow-wave sleep showed lower LF/HF ratio and higher nHF during the first sleep cycle. In fact, compared to baseline recordings, sleepwalkers, but not controls, showed a significant decrease in nLF and LF/HF ratio as well as increased nHF during recovery slow-wave sleep during the first cycle. Although non-significant, similar findings with medium effect sizes were observed for absolute values (LF, HF). Patterns of autonomic modulation during sleepwalkers' recovery slow-wave sleep suggest parasympathetic dominance as compared to baseline sleep values and to controls. This parasympathetic predominance may be a marker of abnormal neural mechanisms underlying, or interfere with, the arousal processes and contribute to the pathophysiology of sleepwalking.
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spelling pubmed-82638992021-07-09 Autonomic Modulation During Baseline and Recovery Sleep in Adult Sleepwalkers Scavone, Geneviève Baril, Andrée-Ann Montplaisir, Jacques Carrier, Julie Desautels, Alex Zadra, Antonio Front Neurol Neurology Sleepwalking has been conceptualized as deregulation between slow-wave sleep and arousal, with its occurrence in predisposed patients increasing following sleep deprivation. Recent evidence showed autonomic changes before arousals and somnambulistic episodes, suggesting that autonomic dysfunctions may contribute to the pathophysiology of sleepwalking. We investigated cardiac autonomic modulation during slow-wave sleep in sleepwalkers and controls during normal and recovery sleep following sleep deprivation. Fourteen adult sleepwalkers (5M; 28.1 ± 5.8 years) and 14 sex- and age-matched normal controls were evaluated by video-polysomnography for one baseline night and during recovery sleep following 25 h of sleep deprivation. Autonomic modulation was investigated with heart rate variability during participants' slow-wave sleep in their first and second sleep cycles. 5-min electrocardiographic segments from slow-wave sleep were analyzed to investigate low-frequency (LF) and high-frequency (HF) components of heart rate spectral decomposition. Group (sleepwalkers, controls) X condition (baseline, recovery) ANOVAs were performed to compare LF and HF in absolute and normalized units (nLF and nHF), and LF/HF ratio. When compared to controls, sleepwalkers' recovery slow-wave sleep showed lower LF/HF ratio and higher nHF during the first sleep cycle. In fact, compared to baseline recordings, sleepwalkers, but not controls, showed a significant decrease in nLF and LF/HF ratio as well as increased nHF during recovery slow-wave sleep during the first cycle. Although non-significant, similar findings with medium effect sizes were observed for absolute values (LF, HF). Patterns of autonomic modulation during sleepwalkers' recovery slow-wave sleep suggest parasympathetic dominance as compared to baseline sleep values and to controls. This parasympathetic predominance may be a marker of abnormal neural mechanisms underlying, or interfere with, the arousal processes and contribute to the pathophysiology of sleepwalking. Frontiers Media S.A. 2021-06-24 /pmc/articles/PMC8263899/ /pubmed/34248823 http://dx.doi.org/10.3389/fneur.2021.680596 Text en Copyright © 2021 Scavone, Baril, Montplaisir, Carrier, Desautels and Zadra. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Scavone, Geneviève
Baril, Andrée-Ann
Montplaisir, Jacques
Carrier, Julie
Desautels, Alex
Zadra, Antonio
Autonomic Modulation During Baseline and Recovery Sleep in Adult Sleepwalkers
title Autonomic Modulation During Baseline and Recovery Sleep in Adult Sleepwalkers
title_full Autonomic Modulation During Baseline and Recovery Sleep in Adult Sleepwalkers
title_fullStr Autonomic Modulation During Baseline and Recovery Sleep in Adult Sleepwalkers
title_full_unstemmed Autonomic Modulation During Baseline and Recovery Sleep in Adult Sleepwalkers
title_short Autonomic Modulation During Baseline and Recovery Sleep in Adult Sleepwalkers
title_sort autonomic modulation during baseline and recovery sleep in adult sleepwalkers
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263899/
https://www.ncbi.nlm.nih.gov/pubmed/34248823
http://dx.doi.org/10.3389/fneur.2021.680596
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