Therapeutic Response of Soft Tissue Sarcoma With Novel SS18-POU5F1 Fusion: A Case Report

A novel SS18-POU5F1 fusion gene was recently reported in soft tissue sarcoma occurring in three adolescent and young adult patients. Herein, we firstly reported the treatment response of SS18-POU5F1 sarcoma to immune checkpoint inhibitor, angiogenesis inhibitor, chemotherapy and radiotherapy. Our pa...

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Detalles Bibliográficos
Autores principales: Liu, Zengjun, Yuan, Hongtu, Han, Mingyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263906/
https://www.ncbi.nlm.nih.gov/pubmed/34249705
http://dx.doi.org/10.3389/fonc.2021.666946
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author Liu, Zengjun
Yuan, Hongtu
Han, Mingyong
author_facet Liu, Zengjun
Yuan, Hongtu
Han, Mingyong
author_sort Liu, Zengjun
collection PubMed
description A novel SS18-POU5F1 fusion gene was recently reported in soft tissue sarcoma occurring in three adolescent and young adult patients. Herein, we firstly reported the treatment response of SS18-POU5F1 sarcoma to immune checkpoint inhibitor, angiogenesis inhibitor, chemotherapy and radiotherapy. Our patient demonstrated no response to various systemic therapies including immune checkpoint inhibitor, angiogenesis inhibitor and chemotherapy. However, we noted that the SS18-POU5F1 sarcoma had a quick, robust but transient clinical response to radiotherapy. Further studies are needed to elucidate the mechanism underlying the different tumor response to radiotherapy and systemic therapy in this kind of tumor.
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spelling pubmed-82639062021-07-09 Therapeutic Response of Soft Tissue Sarcoma With Novel SS18-POU5F1 Fusion: A Case Report Liu, Zengjun Yuan, Hongtu Han, Mingyong Front Oncol Oncology A novel SS18-POU5F1 fusion gene was recently reported in soft tissue sarcoma occurring in three adolescent and young adult patients. Herein, we firstly reported the treatment response of SS18-POU5F1 sarcoma to immune checkpoint inhibitor, angiogenesis inhibitor, chemotherapy and radiotherapy. Our patient demonstrated no response to various systemic therapies including immune checkpoint inhibitor, angiogenesis inhibitor and chemotherapy. However, we noted that the SS18-POU5F1 sarcoma had a quick, robust but transient clinical response to radiotherapy. Further studies are needed to elucidate the mechanism underlying the different tumor response to radiotherapy and systemic therapy in this kind of tumor. Frontiers Media S.A. 2021-06-24 /pmc/articles/PMC8263906/ /pubmed/34249705 http://dx.doi.org/10.3389/fonc.2021.666946 Text en Copyright © 2021 Liu, Yuan and Han https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liu, Zengjun
Yuan, Hongtu
Han, Mingyong
Therapeutic Response of Soft Tissue Sarcoma With Novel SS18-POU5F1 Fusion: A Case Report
title Therapeutic Response of Soft Tissue Sarcoma With Novel SS18-POU5F1 Fusion: A Case Report
title_full Therapeutic Response of Soft Tissue Sarcoma With Novel SS18-POU5F1 Fusion: A Case Report
title_fullStr Therapeutic Response of Soft Tissue Sarcoma With Novel SS18-POU5F1 Fusion: A Case Report
title_full_unstemmed Therapeutic Response of Soft Tissue Sarcoma With Novel SS18-POU5F1 Fusion: A Case Report
title_short Therapeutic Response of Soft Tissue Sarcoma With Novel SS18-POU5F1 Fusion: A Case Report
title_sort therapeutic response of soft tissue sarcoma with novel ss18-pou5f1 fusion: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263906/
https://www.ncbi.nlm.nih.gov/pubmed/34249705
http://dx.doi.org/10.3389/fonc.2021.666946
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AT yuanhongtu therapeuticresponseofsofttissuesarcomawithnovelss18pou5f1fusionacasereport
AT hanmingyong therapeuticresponseofsofttissuesarcomawithnovelss18pou5f1fusionacasereport

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