Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application

N4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized. The synthesized ligands, complexes, and polymers were purified and characterized to study the structure of the molecule. These synthesized complexes were used for phot...

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Autores principales: Prabhu C. P., Keshavananda, Nemakal, Manjunatha, Managa, Muthumuni, Nyokong, Tebello, Koodlur Sannegowda, Lokesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263923/
https://www.ncbi.nlm.nih.gov/pubmed/34249856
http://dx.doi.org/10.3389/fchem.2021.647331
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author Prabhu C. P., Keshavananda
Nemakal, Manjunatha
Managa, Muthumuni
Nyokong, Tebello
Koodlur Sannegowda, Lokesh
author_facet Prabhu C. P., Keshavananda
Nemakal, Manjunatha
Managa, Muthumuni
Nyokong, Tebello
Koodlur Sannegowda, Lokesh
author_sort Prabhu C. P., Keshavananda
collection PubMed
description N4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized. The synthesized ligands, complexes, and polymers were purified and characterized to study the structure of the molecule. These synthesized complexes were used for photodynamic therapy application as the diamagnetic Zn and Al have the ability to produce and stabilize singlet oxygen species. The synthesized N4 molecules of aluminum iminomethoxy phenyl phthalocyanine and aluminum ethyl phenyl benzimidazolephthalocyanine showed better activity against MCF-7 cells. These results suggest that this assay may be used as an early biomarker of clinical response.
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spelling pubmed-82639232021-07-09 Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application Prabhu C. P., Keshavananda Nemakal, Manjunatha Managa, Muthumuni Nyokong, Tebello Koodlur Sannegowda, Lokesh Front Chem Chemistry N4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized. The synthesized ligands, complexes, and polymers were purified and characterized to study the structure of the molecule. These synthesized complexes were used for photodynamic therapy application as the diamagnetic Zn and Al have the ability to produce and stabilize singlet oxygen species. The synthesized N4 molecules of aluminum iminomethoxy phenyl phthalocyanine and aluminum ethyl phenyl benzimidazolephthalocyanine showed better activity against MCF-7 cells. These results suggest that this assay may be used as an early biomarker of clinical response. Frontiers Media S.A. 2021-06-24 /pmc/articles/PMC8263923/ /pubmed/34249856 http://dx.doi.org/10.3389/fchem.2021.647331 Text en Copyright © 2021 Prabhu C. P., Nemakal, Managa, Nyokong and Koodlur Sannegowda. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Prabhu C. P., Keshavananda
Nemakal, Manjunatha
Managa, Muthumuni
Nyokong, Tebello
Koodlur Sannegowda, Lokesh
Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application
title Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application
title_full Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application
title_fullStr Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application
title_full_unstemmed Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application
title_short Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application
title_sort symmetrically substituted zn and al phthalocyanines and polymers for photodynamic therapy application
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263923/
https://www.ncbi.nlm.nih.gov/pubmed/34249856
http://dx.doi.org/10.3389/fchem.2021.647331
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