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HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD–ligand interactions

The human voltage-gated proton channel Hv1 is a drug target for cancer, ischemic stroke, and neuroinflammation. It resides on the plasma membrane and endocytic compartments of a variety of cell types, where it mediates outward proton movement and regulates the activity of NOX enzymes. Its voltage-se...

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Detalles Bibliográficos
Autores principales:	Zhao, Chang, Hong, Liang, Galpin, Jason D., Riahi, Saleh, Lim, Victoria T., Webster, Parker D., Tobias, Douglas J., Ahern, Christopher A., Tombola, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263924/ https://www.ncbi.nlm.nih.gov/pubmed/34228044 http://dx.doi.org/10.1085/jgp.202012832

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