Pharmaco-transcriptomic correlation analysis reveals novel responsive signatures to HDAC inhibitors and identifies Dasatinib as a synergistic interactor in small-cell lung cancer

BACKGROUND: Histone acetylation/deacetylase process is one of the most studied epigenetic modifications. Histone deacetylase inhibitors (HDACis) have shown clinical benefits in haematological malignancies but failed in solid tumours due to the lack of biomarker-driven stratification. METHODS: We per...

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Detalles Bibliográficos
Autores principales: Yang, Haitang, Sun, Beibei, Xu, Ke, He, Yunfei, Zhang, Tuo, Hall, Sean R R, Tan, Swee T., Schmid, Ralph A., Peng, Ren-Wang, Hu, Guohong, Yao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264109/
https://www.ncbi.nlm.nih.gov/pubmed/34224975
http://dx.doi.org/10.1016/j.ebiom.2021.103457

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