Perturbed DNA methylation by Gadd45b induces chromatin disorganization, DNA strand breaks and dopaminergic neuron death

Age is a major risk factor for neurodegenerative diseases like Parkinson’s disease, but few studies have explored the contribution of key hallmarks of aging, namely DNA methylation changes and heterochromatin destructuration, in the neurodegenerative process. Here, we investigated the consequences o...

Descripción completa

Detalles Bibliográficos
Autores principales: Ravel-Godreuil, Camille, Massiani-Beaudoin, Olivia, Mailly, Philippe, Prochiantz, Alain, Joshi, Rajiv L., Fuchs, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264156/
https://www.ncbi.nlm.nih.gov/pubmed/34278264
http://dx.doi.org/10.1016/j.isci.2021.102756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264156/
https://www.ncbi.nlm.nih.gov/pubmed/34278264
http://dx.doi.org/10.1016/j.isci.2021.102756

Ejemplares similares