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Extensive three-dimensional intratumor proteomic heterogeneity revealed by multiregion sampling in high-grade serous ovarian tumor specimens

Enriched tumor epithelium, tumor-associated stroma, and whole tissue were collected by laser microdissection from thin sections across spatially separated levels of ten high-grade serous ovarian carcinomas (HGSOCs) and analyzed by mass spectrometry, reverse phase protein arrays, and RNA sequencing....

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Detalles Bibliográficos
Autores principales: Hunt, Allison L., Bateman, Nicholas W., Barakat, Waleed, Makohon-Moore, Sasha, Hood, Brian L., Conrads, Kelly A., Zhou, Ming, Calvert, Valerie, Pierobon, Mariaelena, Loffredo, Jeremy, Litzi, Tracy J., Oliver, Julie, Mitchell, Dave, Gist, Glenn, Rojas, Christine, Blanton, Brian, Robinson, Emma L., Odunsi, Kunle, Sood, Anil K., Casablanca, Yovanni, Darcy, Kathleen M., Shriver, Craig D., Petricoin, Emanuel F., Rao, Uma N.M., Maxwell, G. Larry, Conrads, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264160/
https://www.ncbi.nlm.nih.gov/pubmed/34278265
http://dx.doi.org/10.1016/j.isci.2021.102757