Cargando…

Human Metapneumovirus Induces IRF1 via TANK-Binding Kinase 1 and Type I IFN

The innate immune and host-protective responses to viruses, such as the airway pathogen human metapneumovirus (HMPV), depend on interferons (IFNs) that is induced through TANK-binding kinase 1 (TBK1) and IFN regulatory factors (IRFs). The transcription factor IRF1 is important for host resistance ag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Loevenich, Simon, Spahn, Alix S., Rian, Kristin, Boyartchuk, Victor, Anthonsen, Marit Walbye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264192/ https://www.ncbi.nlm.nih.gov/pubmed/34248923 http://dx.doi.org/10.3389/fimmu.2021.563336

Ejemplares similares

Human metapneumovirus driven IFN-β production antagonizes macrophage transcriptional induction of IL1-β in response to bacterial pathogens
por: Loevenich, Simon, et al.
Publicado: (2023)

Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity
por: Loevenich, Simon, et al.
Publicado: (2018)

TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation
por: Hu, Yi Wei, et al.
Publicado: (2018)

Characterization of signaling pathways regulating the expression of pro-inflammatory long form thymic stromal lymphopoietin upon human metapneumovirus infection
por: Li, Youxian, et al.
Publicado: (2018)

TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity
por: Louis, Cynthia, et al.
Publicado: (2018)

Cytokine Profiles in Human Metapneumovirus Infected Children: Identification of Genes Involved in the Antiviral Response and Pathogenesis
por: Malmo, Jostein, et al.
Publicado: (2016)

Regulating IRFs in IFN Driven Disease
por: Jefferies, Caroline A.
Publicado: (2019)

Promoter Binding and Nuclear Retention Features of Zebrafish IRF Family Members in IFN Response
por: An, Li-Li, et al.
Publicado: (2022)

Grass Carp (Ctenopharyngodon idella) KAT8 Inhibits IFN 1 Response Through Acetylating IRF3/IRF7
por: Li, Meifeng, et al.
Publicado: (2022)

ISR8/IRF1-AS1 Is Relevant for IFNα and NF-κB Responses
por: Barriocanal, Marina, et al.
Publicado: (2022)

Cell-Type-Specific Transcription of Innate Immune Regulators in response to HMPV Infection
por: Loevenich, Simon, et al.
Publicado: (2019)

The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis
por: Occhigrossi, Luca, et al.
Publicado: (2023)

TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration
por: Jiang, Yuchuan, et al.
Publicado: (2021)

IRF-7 Mediates Type I IFN Responses in Endotoxin-Challenged Mice
por: Sin, Wei-Xiang, et al.
Publicado: (2020)

Epstein-Barr Virus Early Protein BFRF1 Suppresses IFN-β Activity by Inhibiting the Activation of IRF3
por: Wang, Ping, et al.
Publicado: (2020)

Grass Carp (Ctenopharyngodon idellus) NIMA-Related Kinase 6 Blocks dsRNA-Induced IFN I Response by Targeting IRF3
por: Xu, Xiaowen, et al.
Publicado: (2021)

Chicken DDX3X Activates IFN-β via the chSTING-chIRF7-IFN-β Signaling Axis
por: Niu, Qiaona, et al.
Publicado: (2019)

Mutation in Irf8 Gene (Irf8(R294C) ) Impairs Type I IFN-Mediated Antiviral Immune Response by Murine pDCs
por: Das, Annesa, et al.
Publicado: (2021)

A Novel Transcript Isoform of TBK1 Negatively Regulates Type I IFN Production by Promoting Proteasomal Degradation of TBK1 and Lysosomal Degradation of IRF3
por: Zhang, Jie, et al.
Publicado: (2020)

IRF3 and IRF7 require SIRT1 for liquid–liquid phase separation and transactivation of IFN-1
Publicado: (2022)

TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1
por: Zhang, Meng, et al.
Publicado: (2012)

Comparative In Silico Analysis and Functional Characterization of TANK-Binding Kinase 1–Binding Protein 1
por: Sawal, Humaira Aziz, et al.
Publicado: (2023)

IRF-1 is critical for IFNγ mediated immune surveillance
por: Ksienzyk, Antje, et al.
Publicado: (2012)

Irf3 Polymorphism Alters Induction of Interferon Beta in Response to Listeria monocytogenes Infection
por: Garifulin, Oleg, et al.
Publicado: (2007)

An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells
por: Davies, James, et al.
Publicado: (2021)

PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish
por: Zhao, Xin, et al.
Publicado: (2022)

RSV replication modifies the XBP1s binding complex on the IRF1 upstream enhancer to potentiate the mucosal anti-viral response
por: Qiao, Dianhua, et al.
Publicado: (2023)

Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis
por: Pillai, Smitha, et al.
Publicado: (2015)

Foot-and-Mouth Disease Virus Capsid Protein VP1 Antagonizes TPL2-Mediated Activation of the IRF3/IFN-β Signaling Pathway to Facilitate the Virus Replication
por: Hao, Junhong, et al.
Publicado: (2021)

Pim1 promotes IFN-β production by interacting with IRF3
por: Ko, Ryeojin, et al.
Publicado: (2022)

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria
por: Rosain, Jérémie, et al.
Publicado: (2023)

Corrigendum: Foot-and-Mouth Disease Virus Capsid Protein VP1 Antagonizes TPL2-Mediated Activation of the IRF3/IFN-β Signaling Pathway to Facilitate the Virus Replication
por: Hao, Junhong, et al.
Publicado: (2021)

Penaeus monodon Interferon Regulatory Factor (PmIRF) Activates IFNs and Antimicrobial Peptide Expression via a STING-Dependent DNA Sensing Pathway
por: Soponpong, Suthinee, et al.
Publicado: (2022)

Role of human metapneumovirus glycoprotein G in modulation of immune responses
por: Velayutham, Thangam Sudha, et al.
Publicado: (2022)

IRF-1 responsiveness to IFN-γ predicts different cancer immune phenotypes
por: Murtas, D, et al.
Publicado: (2013)

Functional characterization of goose IRF1 in IFN induction and anti-NDV infection
por: Lin, Zhenyu, et al.
Publicado: (2022)

NEMO Binds Ubiquitinated TANK-Binding Kinase 1 (TBK1) to Regulate Innate Immune Responses to RNA Viruses
por: Wang, Lingyan, et al.
Publicado: (2012)

Human Metapneumovirus Inhibits IFN-β Signaling by Downregulating Jak1 and Tyk2 Cellular Levels
por: Ren, Junping, et al.
Publicado: (2011)

Cleavage of TANK-Binding Kinase 1 by HIV-1 Protease Triggers Viral Innate Immune Evasion
por: Jeremiah, Sundararaj Stanleyraj, et al.
Publicado: (2021)

Commentary: Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity
por: Freischmidt, Axel, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4k0s81j0og0i1nvnh0bsi2scjk