Evaluation of Peripheral Immune Activation in Amyotrophic Lateral Sclerosis

Accumulating evidence has revealed that immunity plays an important role in amyotrophic lateral sclerosis (ALS) progression. However, the results regarding the serum levels of immunoglobulin and complement are inconsistent in patients with ALS. Although immune dysfunctions have also been reported in...

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Autores principales: Wang, Mengli, Liu, Zhen, Du, Juan, Yuan, Yanchun, Jiao, Bin, Zhang, Xuewei, Hou, Xuan, Shen, Lu, Guo, Jifeng, Jiang, Hong, Xia, Kun, Tang, Jianguang, Zhang, Ruxu, Tang, Beisha, Wang, Junling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264193/
https://www.ncbi.nlm.nih.gov/pubmed/34248812
http://dx.doi.org/10.3389/fneur.2021.628710
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author Wang, Mengli
Liu, Zhen
Du, Juan
Yuan, Yanchun
Jiao, Bin
Zhang, Xuewei
Hou, Xuan
Shen, Lu
Guo, Jifeng
Jiang, Hong
Xia, Kun
Tang, Jianguang
Zhang, Ruxu
Tang, Beisha
Wang, Junling
author_facet Wang, Mengli
Liu, Zhen
Du, Juan
Yuan, Yanchun
Jiao, Bin
Zhang, Xuewei
Hou, Xuan
Shen, Lu
Guo, Jifeng
Jiang, Hong
Xia, Kun
Tang, Jianguang
Zhang, Ruxu
Tang, Beisha
Wang, Junling
author_sort Wang, Mengli
collection PubMed
description Accumulating evidence has revealed that immunity plays an important role in amyotrophic lateral sclerosis (ALS) progression. However, the results regarding the serum levels of immunoglobulin and complement are inconsistent in patients with ALS. Although immune dysfunctions have also been reported in patients with other neurodegenerative diseases, few studies have explored whether immune dysfunction in ALS is similar to that in other neurodegenerative diseases. Therefore, we performed this study to address these gaps. In the present study, serum levels of immunoglobulin and complement were measured in 245 patients with ALS, 65 patients with multiple system atrophy (MSA), 60 patients with Parkinson's disease (PD), and 82 healthy controls (HCs). Multiple comparisons revealed that no significant differences existed between patients with ALS and other neurodegenerative diseases in immunoglobulin and complement levels. Meta-analysis based on data from our cohort and eight published articles was performed to evaluate the serum immunoglobulin and complement between patients with ALS and HCs. The pooled results showed that patients with ALS had higher C4 levels than HCs. In addition, we found that the IgG levels were lower in early-onset ALS patients than in late-onset ALS patients and HCs, and the correlations between age at onset of ALS and IgG or IgA levels were significant positive. In conclusion, our data supplement existing literature on understanding the role of peripheral immunity in ALS.
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spelling pubmed-82641932021-07-09 Evaluation of Peripheral Immune Activation in Amyotrophic Lateral Sclerosis Wang, Mengli Liu, Zhen Du, Juan Yuan, Yanchun Jiao, Bin Zhang, Xuewei Hou, Xuan Shen, Lu Guo, Jifeng Jiang, Hong Xia, Kun Tang, Jianguang Zhang, Ruxu Tang, Beisha Wang, Junling Front Neurol Neurology Accumulating evidence has revealed that immunity plays an important role in amyotrophic lateral sclerosis (ALS) progression. However, the results regarding the serum levels of immunoglobulin and complement are inconsistent in patients with ALS. Although immune dysfunctions have also been reported in patients with other neurodegenerative diseases, few studies have explored whether immune dysfunction in ALS is similar to that in other neurodegenerative diseases. Therefore, we performed this study to address these gaps. In the present study, serum levels of immunoglobulin and complement were measured in 245 patients with ALS, 65 patients with multiple system atrophy (MSA), 60 patients with Parkinson's disease (PD), and 82 healthy controls (HCs). Multiple comparisons revealed that no significant differences existed between patients with ALS and other neurodegenerative diseases in immunoglobulin and complement levels. Meta-analysis based on data from our cohort and eight published articles was performed to evaluate the serum immunoglobulin and complement between patients with ALS and HCs. The pooled results showed that patients with ALS had higher C4 levels than HCs. In addition, we found that the IgG levels were lower in early-onset ALS patients than in late-onset ALS patients and HCs, and the correlations between age at onset of ALS and IgG or IgA levels were significant positive. In conclusion, our data supplement existing literature on understanding the role of peripheral immunity in ALS. Frontiers Media S.A. 2021-06-24 /pmc/articles/PMC8264193/ /pubmed/34248812 http://dx.doi.org/10.3389/fneur.2021.628710 Text en Copyright © 2021 Wang, Liu, Du, Yuan, Jiao, Zhang, Hou, Shen, Guo, Jiang, Xia, Tang, Zhang, Tang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Wang, Mengli
Liu, Zhen
Du, Juan
Yuan, Yanchun
Jiao, Bin
Zhang, Xuewei
Hou, Xuan
Shen, Lu
Guo, Jifeng
Jiang, Hong
Xia, Kun
Tang, Jianguang
Zhang, Ruxu
Tang, Beisha
Wang, Junling
Evaluation of Peripheral Immune Activation in Amyotrophic Lateral Sclerosis
title Evaluation of Peripheral Immune Activation in Amyotrophic Lateral Sclerosis
title_full Evaluation of Peripheral Immune Activation in Amyotrophic Lateral Sclerosis
title_fullStr Evaluation of Peripheral Immune Activation in Amyotrophic Lateral Sclerosis
title_full_unstemmed Evaluation of Peripheral Immune Activation in Amyotrophic Lateral Sclerosis
title_short Evaluation of Peripheral Immune Activation in Amyotrophic Lateral Sclerosis
title_sort evaluation of peripheral immune activation in amyotrophic lateral sclerosis
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264193/
https://www.ncbi.nlm.nih.gov/pubmed/34248812
http://dx.doi.org/10.3389/fneur.2021.628710
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