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Case Report: Freeze-Dried Human Amniotic Membrane Allograft for the Treatment of Chronic Wounds: Results of a Multicentre Observational Study

An inability of the human body to heal acute wounds under certain conditions results in the formation of chronic ulcers. Chronic wounds not only cause significant pain and discomfort for patients but also serve as an entry for microorganisms into the human body, which can result in serious life-thre...

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Autores principales: Schmiedova, Iveta, Ozanova, Zuzana, Stastna, Elen, Kiselakova, Ludmila, Lipovy, Bretislav, Forostyak, Serhiy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264202/
https://www.ncbi.nlm.nih.gov/pubmed/34249879
http://dx.doi.org/10.3389/fbioe.2021.649446
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author Schmiedova, Iveta
Ozanova, Zuzana
Stastna, Elen
Kiselakova, Ludmila
Lipovy, Bretislav
Forostyak, Serhiy
author_facet Schmiedova, Iveta
Ozanova, Zuzana
Stastna, Elen
Kiselakova, Ludmila
Lipovy, Bretislav
Forostyak, Serhiy
author_sort Schmiedova, Iveta
collection PubMed
description An inability of the human body to heal acute wounds under certain conditions results in the formation of chronic ulcers. Chronic wounds not only cause significant pain and discomfort for patients but also serve as an entry for microorganisms into the human body, which can result in serious life-threatening problems and become a significant burden for the patients and society. The current work present results of a multicentre prospective observational study demonstrating the use of a lyophilized amniotic membrane (AM) in the treatment of chronic wounds (various etiologies). Lyophilized AM produced under the commercial brand Amnioderm® was used as an allograft material for therapy of chronic wounds, in addition to chronic ulcer standard-of-care (SoC) protocols. The duration of wounds considered for the application of AM ranged between 2 months and 11 years. In total, 16 patients were enrolled to the study, of which eight were completely healed, six demonstrated a significantly reduced ulcer size, and two did not respond to the AM therapy. The current study unambiguously demonstrates an effective alternative to the standard of chronic wound care and confirms a significant effect of the AM application for chronic wound management as a new SoC.
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spelling pubmed-82642022021-07-09 Case Report: Freeze-Dried Human Amniotic Membrane Allograft for the Treatment of Chronic Wounds: Results of a Multicentre Observational Study Schmiedova, Iveta Ozanova, Zuzana Stastna, Elen Kiselakova, Ludmila Lipovy, Bretislav Forostyak, Serhiy Front Bioeng Biotechnol Bioengineering and Biotechnology An inability of the human body to heal acute wounds under certain conditions results in the formation of chronic ulcers. Chronic wounds not only cause significant pain and discomfort for patients but also serve as an entry for microorganisms into the human body, which can result in serious life-threatening problems and become a significant burden for the patients and society. The current work present results of a multicentre prospective observational study demonstrating the use of a lyophilized amniotic membrane (AM) in the treatment of chronic wounds (various etiologies). Lyophilized AM produced under the commercial brand Amnioderm® was used as an allograft material for therapy of chronic wounds, in addition to chronic ulcer standard-of-care (SoC) protocols. The duration of wounds considered for the application of AM ranged between 2 months and 11 years. In total, 16 patients were enrolled to the study, of which eight were completely healed, six demonstrated a significantly reduced ulcer size, and two did not respond to the AM therapy. The current study unambiguously demonstrates an effective alternative to the standard of chronic wound care and confirms a significant effect of the AM application for chronic wound management as a new SoC. Frontiers Media S.A. 2021-06-24 /pmc/articles/PMC8264202/ /pubmed/34249879 http://dx.doi.org/10.3389/fbioe.2021.649446 Text en Copyright © 2021 Schmiedova, Ozanova, Stastna, Kiselakova, Lipovy and Forostyak. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Schmiedova, Iveta
Ozanova, Zuzana
Stastna, Elen
Kiselakova, Ludmila
Lipovy, Bretislav
Forostyak, Serhiy
Case Report: Freeze-Dried Human Amniotic Membrane Allograft for the Treatment of Chronic Wounds: Results of a Multicentre Observational Study
title Case Report: Freeze-Dried Human Amniotic Membrane Allograft for the Treatment of Chronic Wounds: Results of a Multicentre Observational Study
title_full Case Report: Freeze-Dried Human Amniotic Membrane Allograft for the Treatment of Chronic Wounds: Results of a Multicentre Observational Study
title_fullStr Case Report: Freeze-Dried Human Amniotic Membrane Allograft for the Treatment of Chronic Wounds: Results of a Multicentre Observational Study
title_full_unstemmed Case Report: Freeze-Dried Human Amniotic Membrane Allograft for the Treatment of Chronic Wounds: Results of a Multicentre Observational Study
title_short Case Report: Freeze-Dried Human Amniotic Membrane Allograft for the Treatment of Chronic Wounds: Results of a Multicentre Observational Study
title_sort case report: freeze-dried human amniotic membrane allograft for the treatment of chronic wounds: results of a multicentre observational study
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264202/
https://www.ncbi.nlm.nih.gov/pubmed/34249879
http://dx.doi.org/10.3389/fbioe.2021.649446
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