The Non-Steroidal Mineralocorticoid Receptor Antagonist KBP-5074 Limits Albuminuria and has Improved Therapeutic Index Compared With Eplerenone in a Rat Model With Mineralocorticoid-Induced Renal Injury

The therapeutic indices (TIs) and efficacy of the non-steroidal mineralocorticoid receptor antagonist (MRA) KBP-5074 and steroidal MRA eplerenone were evaluated in a uninephrectomized Sprague Dawley rat model of aldosterone-mediated renal disease. In two parallel studies, rats were placed on a high-...

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Detalles Bibliográficos
Autores principales: Jaisser, Frédéric, Tan, Xiaojuan, Chi, Shuangshuang, Liu, Jinrong, Wang, Ping, Bush, Mark, Benn, Vincent, Yang, Y. Fred, Zhang, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264204/
https://www.ncbi.nlm.nih.gov/pubmed/34248613
http://dx.doi.org/10.3389/fphar.2021.604928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264204/
https://www.ncbi.nlm.nih.gov/pubmed/34248613
http://dx.doi.org/10.3389/fphar.2021.604928

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