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One‐year estimated glomerular filtration rate decline as a risk factor of cardiovascular and renal end‐points in high‐risk Japanese patients
AIMS/INTRODUCTION: As estimated glomerular filtration rate (eGFR) progression might correlate with cardiovascular prognosis, the correlation between 1‐year decline in eGFR and cardiovascular incidences and renal outcome was investigated. MATERIALS AND METHODS: The 1‐year percentage decline in eGFR a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264407/ https://www.ncbi.nlm.nih.gov/pubmed/33277819 http://dx.doi.org/10.1111/jdi.13474 |
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author | Meguro, Shu Inaishi, Jun Sato, Yasunori Komuro, Issei Itoh, Hiroshi |
author_facet | Meguro, Shu Inaishi, Jun Sato, Yasunori Komuro, Issei Itoh, Hiroshi |
author_sort | Meguro, Shu |
collection | PubMed |
description | AIMS/INTRODUCTION: As estimated glomerular filtration rate (eGFR) progression might correlate with cardiovascular prognosis, the correlation between 1‐year decline in eGFR and cardiovascular incidences and renal outcome was investigated. MATERIALS AND METHODS: The 1‐year percentage decline in eGFR at the first observation year was calculated in a cohort of the standard versus intEnsive statin therapy for hypercholesteroleMic Patients with diAbetic retinopaTHY (EMPATHY) trial participants. The primary end‐point was the composite cardiovascular end‐point including the renal end‐point. The associations between the incidence of each end‐point and clinical markers were analyzed using the Cox proportional hazards regression model. RESULTS: A total of 4,461 patients were analyzed. The mean observation period was 765.3 ± 363.1 days. The best cut‐off value of 1‐year eGFR decline was 0.099 in the first year for renal end‐point prediction by receiver operating characteristic curve analysis. The area under the curve of the model including the 1‐year eGFR decline of the first year was significantly larger than the model without it (0.943, 95% confidence interval 0.915–0.971 to 0.967, 95% confidence interval 0.950–0.983, P = 0.019). Primary end‐point incidences and the renal end‐point were much higher in rapid eGFR decliners compared with non‐decliners (P < 0.0001). The cardiovascular end‐point incidence, except for the renal end‐point, was not different between the groups. According to Cox regression analysis, 1‐year eGFR decline during the first year was a significant risk factor for the end‐points, including the renal end‐point, independent of albuminuria and eGFR at baseline. CONCLUSIONS: The 1‐year eGFR decline rate provided useful information for cardiovascular end‐point predictions, including the renal end‐point, in addition to the conventional risk factors. |
format | Online Article Text |
id | pubmed-8264407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82644072021-07-13 One‐year estimated glomerular filtration rate decline as a risk factor of cardiovascular and renal end‐points in high‐risk Japanese patients Meguro, Shu Inaishi, Jun Sato, Yasunori Komuro, Issei Itoh, Hiroshi J Diabetes Investig Articles AIMS/INTRODUCTION: As estimated glomerular filtration rate (eGFR) progression might correlate with cardiovascular prognosis, the correlation between 1‐year decline in eGFR and cardiovascular incidences and renal outcome was investigated. MATERIALS AND METHODS: The 1‐year percentage decline in eGFR at the first observation year was calculated in a cohort of the standard versus intEnsive statin therapy for hypercholesteroleMic Patients with diAbetic retinopaTHY (EMPATHY) trial participants. The primary end‐point was the composite cardiovascular end‐point including the renal end‐point. The associations between the incidence of each end‐point and clinical markers were analyzed using the Cox proportional hazards regression model. RESULTS: A total of 4,461 patients were analyzed. The mean observation period was 765.3 ± 363.1 days. The best cut‐off value of 1‐year eGFR decline was 0.099 in the first year for renal end‐point prediction by receiver operating characteristic curve analysis. The area under the curve of the model including the 1‐year eGFR decline of the first year was significantly larger than the model without it (0.943, 95% confidence interval 0.915–0.971 to 0.967, 95% confidence interval 0.950–0.983, P = 0.019). Primary end‐point incidences and the renal end‐point were much higher in rapid eGFR decliners compared with non‐decliners (P < 0.0001). The cardiovascular end‐point incidence, except for the renal end‐point, was not different between the groups. According to Cox regression analysis, 1‐year eGFR decline during the first year was a significant risk factor for the end‐points, including the renal end‐point, independent of albuminuria and eGFR at baseline. CONCLUSIONS: The 1‐year eGFR decline rate provided useful information for cardiovascular end‐point predictions, including the renal end‐point, in addition to the conventional risk factors. John Wiley and Sons Inc. 2020-12-30 2021-07 /pmc/articles/PMC8264407/ /pubmed/33277819 http://dx.doi.org/10.1111/jdi.13474 Text en © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Articles Meguro, Shu Inaishi, Jun Sato, Yasunori Komuro, Issei Itoh, Hiroshi One‐year estimated glomerular filtration rate decline as a risk factor of cardiovascular and renal end‐points in high‐risk Japanese patients |
title | One‐year estimated glomerular filtration rate decline as a risk factor of cardiovascular and renal end‐points in high‐risk Japanese patients |
title_full | One‐year estimated glomerular filtration rate decline as a risk factor of cardiovascular and renal end‐points in high‐risk Japanese patients |
title_fullStr | One‐year estimated glomerular filtration rate decline as a risk factor of cardiovascular and renal end‐points in high‐risk Japanese patients |
title_full_unstemmed | One‐year estimated glomerular filtration rate decline as a risk factor of cardiovascular and renal end‐points in high‐risk Japanese patients |
title_short | One‐year estimated glomerular filtration rate decline as a risk factor of cardiovascular and renal end‐points in high‐risk Japanese patients |
title_sort | one‐year estimated glomerular filtration rate decline as a risk factor of cardiovascular and renal end‐points in high‐risk japanese patients |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264407/ https://www.ncbi.nlm.nih.gov/pubmed/33277819 http://dx.doi.org/10.1111/jdi.13474 |
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