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Involvement of TRP Channels in Adipocyte Thermogenesis: An Update
Obesity prevalence became a severe global health problem and it is caused by an imbalance between energy intake and expenditure. Brown adipose tissue (BAT) is a major site of mammalian non-shivering thermogenesis or energy dissipation. Thus, modulation of BAT thermogenesis might be a promising appli...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264417/ https://www.ncbi.nlm.nih.gov/pubmed/34249940 http://dx.doi.org/10.3389/fcell.2021.686173 |
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author | Sun, Wuping Luo, Yixuan Zhang, Fei Tang, Shuo Zhu, Tao |
author_facet | Sun, Wuping Luo, Yixuan Zhang, Fei Tang, Shuo Zhu, Tao |
author_sort | Sun, Wuping |
collection | PubMed |
description | Obesity prevalence became a severe global health problem and it is caused by an imbalance between energy intake and expenditure. Brown adipose tissue (BAT) is a major site of mammalian non-shivering thermogenesis or energy dissipation. Thus, modulation of BAT thermogenesis might be a promising application for body weight control and obesity prevention. TRP channels are non-selective calcium-permeable cation channels mainly located on the plasma membrane. As a research focus, TRP channels have been reported to be involved in the thermogenesis of adipose tissue, energy metabolism and body weight regulation. In this review, we will summarize and update the recent progress of the pathological/physiological involvement of TRP channels in adipocyte thermogenesis. Moreover, we will discuss the potential of TRP channels as future therapeutic targets for preventing and combating human obesity and related-metabolic disorders. |
format | Online Article Text |
id | pubmed-8264417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82644172021-07-09 Involvement of TRP Channels in Adipocyte Thermogenesis: An Update Sun, Wuping Luo, Yixuan Zhang, Fei Tang, Shuo Zhu, Tao Front Cell Dev Biol Cell and Developmental Biology Obesity prevalence became a severe global health problem and it is caused by an imbalance between energy intake and expenditure. Brown adipose tissue (BAT) is a major site of mammalian non-shivering thermogenesis or energy dissipation. Thus, modulation of BAT thermogenesis might be a promising application for body weight control and obesity prevention. TRP channels are non-selective calcium-permeable cation channels mainly located on the plasma membrane. As a research focus, TRP channels have been reported to be involved in the thermogenesis of adipose tissue, energy metabolism and body weight regulation. In this review, we will summarize and update the recent progress of the pathological/physiological involvement of TRP channels in adipocyte thermogenesis. Moreover, we will discuss the potential of TRP channels as future therapeutic targets for preventing and combating human obesity and related-metabolic disorders. Frontiers Media S.A. 2021-06-24 /pmc/articles/PMC8264417/ /pubmed/34249940 http://dx.doi.org/10.3389/fcell.2021.686173 Text en Copyright © 2021 Sun, Luo, Zhang, Tang and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Sun, Wuping Luo, Yixuan Zhang, Fei Tang, Shuo Zhu, Tao Involvement of TRP Channels in Adipocyte Thermogenesis: An Update |
title | Involvement of TRP Channels in Adipocyte Thermogenesis: An Update |
title_full | Involvement of TRP Channels in Adipocyte Thermogenesis: An Update |
title_fullStr | Involvement of TRP Channels in Adipocyte Thermogenesis: An Update |
title_full_unstemmed | Involvement of TRP Channels in Adipocyte Thermogenesis: An Update |
title_short | Involvement of TRP Channels in Adipocyte Thermogenesis: An Update |
title_sort | involvement of trp channels in adipocyte thermogenesis: an update |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264417/ https://www.ncbi.nlm.nih.gov/pubmed/34249940 http://dx.doi.org/10.3389/fcell.2021.686173 |
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