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FSCN1 Promotes Radiation Resistance in Patients With PIK3CA Gene Alteration

Radiotherapy is one of the standard treatments for cervical cancer and head and neck cancer. However, the clinical efficacy of this treatment is limited by radioresistance. The discovery of effective prognostic biomarkers and the identification of new therapeutic targets have helped to overcome the...

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Autores principales: Li, Sisi, Huang, Xiao-ting, Wang, Meng-yao, Chen, Dong-ping, Li, Ming-yi, Zhu, Yan-yi, Yu, Yi, Zheng, Lu, Qi, Bin, Liu, Jin-quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264437/
https://www.ncbi.nlm.nih.gov/pubmed/34249689
http://dx.doi.org/10.3389/fonc.2021.653005
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author Li, Sisi
Huang, Xiao-ting
Wang, Meng-yao
Chen, Dong-ping
Li, Ming-yi
Zhu, Yan-yi
Yu, Yi
Zheng, Lu
Qi, Bin
Liu, Jin-quan
author_facet Li, Sisi
Huang, Xiao-ting
Wang, Meng-yao
Chen, Dong-ping
Li, Ming-yi
Zhu, Yan-yi
Yu, Yi
Zheng, Lu
Qi, Bin
Liu, Jin-quan
author_sort Li, Sisi
collection PubMed
description Radiotherapy is one of the standard treatments for cervical cancer and head and neck cancer. However, the clinical efficacy of this treatment is limited by radioresistance. The discovery of effective prognostic biomarkers and the identification of new therapeutic targets have helped to overcome the problem of radioresistance. In this study, we show that in the context of PIK3CA mutation or amplification, high expression of fascin actin-bundling protein 1 (FSCN1) (using the median as the cut-off value) is associated with poor prognosis and radiotherapy response in cancer patients. Silencing FSCN1 enhances radiosensitivity and promotes apoptosis in cancer cells with PIK3CA alterations, and this process may be associated with the downregulation of YWHAZ. These results reveal that FSCN1 may be a key regulator of radioresistance and could be a potential target for improving radiotherapy efficacy in cervical cancer and head and neck cancer patients with PIK3CA alterations.
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spelling pubmed-82644372021-07-09 FSCN1 Promotes Radiation Resistance in Patients With PIK3CA Gene Alteration Li, Sisi Huang, Xiao-ting Wang, Meng-yao Chen, Dong-ping Li, Ming-yi Zhu, Yan-yi Yu, Yi Zheng, Lu Qi, Bin Liu, Jin-quan Front Oncol Oncology Radiotherapy is one of the standard treatments for cervical cancer and head and neck cancer. However, the clinical efficacy of this treatment is limited by radioresistance. The discovery of effective prognostic biomarkers and the identification of new therapeutic targets have helped to overcome the problem of radioresistance. In this study, we show that in the context of PIK3CA mutation or amplification, high expression of fascin actin-bundling protein 1 (FSCN1) (using the median as the cut-off value) is associated with poor prognosis and radiotherapy response in cancer patients. Silencing FSCN1 enhances radiosensitivity and promotes apoptosis in cancer cells with PIK3CA alterations, and this process may be associated with the downregulation of YWHAZ. These results reveal that FSCN1 may be a key regulator of radioresistance and could be a potential target for improving radiotherapy efficacy in cervical cancer and head and neck cancer patients with PIK3CA alterations. Frontiers Media S.A. 2021-06-24 /pmc/articles/PMC8264437/ /pubmed/34249689 http://dx.doi.org/10.3389/fonc.2021.653005 Text en Copyright © 2021 Li, Huang, Wang, Chen, Li, Zhu, Yu, Zheng, Qi and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Sisi
Huang, Xiao-ting
Wang, Meng-yao
Chen, Dong-ping
Li, Ming-yi
Zhu, Yan-yi
Yu, Yi
Zheng, Lu
Qi, Bin
Liu, Jin-quan
FSCN1 Promotes Radiation Resistance in Patients With PIK3CA Gene Alteration
title FSCN1 Promotes Radiation Resistance in Patients With PIK3CA Gene Alteration
title_full FSCN1 Promotes Radiation Resistance in Patients With PIK3CA Gene Alteration
title_fullStr FSCN1 Promotes Radiation Resistance in Patients With PIK3CA Gene Alteration
title_full_unstemmed FSCN1 Promotes Radiation Resistance in Patients With PIK3CA Gene Alteration
title_short FSCN1 Promotes Radiation Resistance in Patients With PIK3CA Gene Alteration
title_sort fscn1 promotes radiation resistance in patients with pik3ca gene alteration
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264437/
https://www.ncbi.nlm.nih.gov/pubmed/34249689
http://dx.doi.org/10.3389/fonc.2021.653005
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