A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronaviruses

BACKGROUND: Our previous studies have shown that combining the antiviral lectin GRFT and the pan-CoV fusion inhibitory peptide EK1 results in highly potent inhibitory activity against SARS-CoV-2 infection. In this study, we aimed to design and construct a bivalent protein consisting of GRFT and EK1...

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Detalles Bibliográficos
Autores principales: Cai, Yanxing, Xu, Wei, Tang, Jiayi, Cao, Najing, Lan, Qiaoshuai, Lu, Lu, Jiang, Shibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264481/
https://www.ncbi.nlm.nih.gov/pubmed/34238357
http://dx.doi.org/10.1186/s13578-021-00638-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264481/
https://www.ncbi.nlm.nih.gov/pubmed/34238357
http://dx.doi.org/10.1186/s13578-021-00638-w

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