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A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronaviruses

BACKGROUND: Our previous studies have shown that combining the antiviral lectin GRFT and the pan-CoV fusion inhibitory peptide EK1 results in highly potent inhibitory activity against SARS-CoV-2 infection. In this study, we aimed to design and construct a bivalent protein consisting of GRFT and EK1...

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Detalles Bibliográficos
Autores principales:	Cai, Yanxing, Xu, Wei, Tang, Jiayi, Cao, Najing, Lan, Qiaoshuai, Lu, Lu, Jiang, Shibo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264481/ https://www.ncbi.nlm.nih.gov/pubmed/34238357 http://dx.doi.org/10.1186/s13578-021-00638-w

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