Cargando…

Effect of Almond Consumption on Metabolic Risk Factors—Glucose Metabolism, Hyperinsulinemia, Selected Markers of Inflammation: A Randomized Controlled Trial in Adolescents and Young Adults

A large percentage of the Indian population has diabetes or is at risk of pre-diabetes. Almond consumption has shown benefits on cardiometabolic risk factors in adults. This study explored the effect of almond consumption on determinants of metabolic dysfunction—blood glucose, lipids, insulin and se...

Descripción completa

Detalles Bibliográficos
Autores principales: Madan, Jagmeet, Desai, Sharvari, Moitra, Panchali, Salis, Sheryl, Agashe, Shubhada, Battalwar, Rekha, Mehta, Anushree, Kamble, Rachana, Kalita, Soumik, Phatak, Ajay Gajanan, Udipi, Shobha A., Vaidya, Rama A., Vaidya, Ashok B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264510/
https://www.ncbi.nlm.nih.gov/pubmed/34249987
http://dx.doi.org/10.3389/fnut.2021.668622
_version_ 1783719573713846272
author Madan, Jagmeet
Desai, Sharvari
Moitra, Panchali
Salis, Sheryl
Agashe, Shubhada
Battalwar, Rekha
Mehta, Anushree
Kamble, Rachana
Kalita, Soumik
Phatak, Ajay Gajanan
Udipi, Shobha A.
Vaidya, Rama A.
Vaidya, Ashok B.
author_facet Madan, Jagmeet
Desai, Sharvari
Moitra, Panchali
Salis, Sheryl
Agashe, Shubhada
Battalwar, Rekha
Mehta, Anushree
Kamble, Rachana
Kalita, Soumik
Phatak, Ajay Gajanan
Udipi, Shobha A.
Vaidya, Rama A.
Vaidya, Ashok B.
author_sort Madan, Jagmeet
collection PubMed
description A large percentage of the Indian population has diabetes or is at risk of pre-diabetes. Almond consumption has shown benefits on cardiometabolic risk factors in adults. This study explored the effect of almond consumption on determinants of metabolic dysfunction—blood glucose, lipids, insulin and selected inflammatory markers in adolescents and young adults aged 16–25 years from Mumbai city. This randomized controlled trial was conducted for a period of 90 days on individuals with impaired levels of fasting glucose levels between 100–125 mg/dL (5.6–6.9 mmol/L) and 2-h post-glucose value 140–199 mg/dL (7.8–11.0 mmol/L) and/or fasting insulin (≥15 mIU/ml)/stimulated insulin (≥80 mIU/ml). Of 1,313 individuals screened, 421 met the inclusion criteria, of which 275 consented to participate and 219 completed the trial. The trial was registered with Clinical Trials Registry India (CTRI) CTRI/2018/02/011927. The almonds group (n = 107) consumed 56 g almonds daily, the control group (n = 112) was provided an iso-caloric cereal-pulse based snack. At baseline and endline, blood glucose, insulin, HbA(1)c, LDL-c, HDL-c, total and ox-cholesterol, triglycerides, hs-CRP, IL-6, TNF-α, adiponectin, leptin were measured and HOMA-IR and FG:FI ratios were calculated. Dietary intakes were assessed. The anthropometric measurements, biochemical markers as well as macronutrient intakes did not differ significantly between the two groups at baseline. Almond consumption significantly decreased HbA(1)c, total cholesterol and LDL-c. Stimulated insulin decreased post-intervention in both groups, but the decrease was greater in the almonds group. Fasting glucose was reduced post intervention in the controls with no change in the almonds group. FG:FI ratio decreased in the almonds group. TNF-α and IL-6 decreased in the almonds group, while it increased in the control group. Our results showed that almonds reduced HbA1c, LDL-c and total cholesterol levels in just 12 weeks of consumption in these adolescents and young adults who were at risk for developing diabetes. Almonds can be considered as part of food-based strategies for preventing pre-diabetes. Clinical Trial Registration: ClinicalTrials.gov, identifier: CTRI/2018/02/011927.
format Online
Article
Text
id pubmed-8264510
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82645102021-07-09 Effect of Almond Consumption on Metabolic Risk Factors—Glucose Metabolism, Hyperinsulinemia, Selected Markers of Inflammation: A Randomized Controlled Trial in Adolescents and Young Adults Madan, Jagmeet Desai, Sharvari Moitra, Panchali Salis, Sheryl Agashe, Shubhada Battalwar, Rekha Mehta, Anushree Kamble, Rachana Kalita, Soumik Phatak, Ajay Gajanan Udipi, Shobha A. Vaidya, Rama A. Vaidya, Ashok B. Front Nutr Nutrition A large percentage of the Indian population has diabetes or is at risk of pre-diabetes. Almond consumption has shown benefits on cardiometabolic risk factors in adults. This study explored the effect of almond consumption on determinants of metabolic dysfunction—blood glucose, lipids, insulin and selected inflammatory markers in adolescents and young adults aged 16–25 years from Mumbai city. This randomized controlled trial was conducted for a period of 90 days on individuals with impaired levels of fasting glucose levels between 100–125 mg/dL (5.6–6.9 mmol/L) and 2-h post-glucose value 140–199 mg/dL (7.8–11.0 mmol/L) and/or fasting insulin (≥15 mIU/ml)/stimulated insulin (≥80 mIU/ml). Of 1,313 individuals screened, 421 met the inclusion criteria, of which 275 consented to participate and 219 completed the trial. The trial was registered with Clinical Trials Registry India (CTRI) CTRI/2018/02/011927. The almonds group (n = 107) consumed 56 g almonds daily, the control group (n = 112) was provided an iso-caloric cereal-pulse based snack. At baseline and endline, blood glucose, insulin, HbA(1)c, LDL-c, HDL-c, total and ox-cholesterol, triglycerides, hs-CRP, IL-6, TNF-α, adiponectin, leptin were measured and HOMA-IR and FG:FI ratios were calculated. Dietary intakes were assessed. The anthropometric measurements, biochemical markers as well as macronutrient intakes did not differ significantly between the two groups at baseline. Almond consumption significantly decreased HbA(1)c, total cholesterol and LDL-c. Stimulated insulin decreased post-intervention in both groups, but the decrease was greater in the almonds group. Fasting glucose was reduced post intervention in the controls with no change in the almonds group. FG:FI ratio decreased in the almonds group. TNF-α and IL-6 decreased in the almonds group, while it increased in the control group. Our results showed that almonds reduced HbA1c, LDL-c and total cholesterol levels in just 12 weeks of consumption in these adolescents and young adults who were at risk for developing diabetes. Almonds can be considered as part of food-based strategies for preventing pre-diabetes. Clinical Trial Registration: ClinicalTrials.gov, identifier: CTRI/2018/02/011927. Frontiers Media S.A. 2021-06-24 /pmc/articles/PMC8264510/ /pubmed/34249987 http://dx.doi.org/10.3389/fnut.2021.668622 Text en Copyright © 2021 Madan, Desai, Moitra, Salis, Agashe, Battalwar, Mehta, Kamble, Kalita, Phatak, Udipi, Vaidya and Vaidya. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Madan, Jagmeet
Desai, Sharvari
Moitra, Panchali
Salis, Sheryl
Agashe, Shubhada
Battalwar, Rekha
Mehta, Anushree
Kamble, Rachana
Kalita, Soumik
Phatak, Ajay Gajanan
Udipi, Shobha A.
Vaidya, Rama A.
Vaidya, Ashok B.
Effect of Almond Consumption on Metabolic Risk Factors—Glucose Metabolism, Hyperinsulinemia, Selected Markers of Inflammation: A Randomized Controlled Trial in Adolescents and Young Adults
title Effect of Almond Consumption on Metabolic Risk Factors—Glucose Metabolism, Hyperinsulinemia, Selected Markers of Inflammation: A Randomized Controlled Trial in Adolescents and Young Adults
title_full Effect of Almond Consumption on Metabolic Risk Factors—Glucose Metabolism, Hyperinsulinemia, Selected Markers of Inflammation: A Randomized Controlled Trial in Adolescents and Young Adults
title_fullStr Effect of Almond Consumption on Metabolic Risk Factors—Glucose Metabolism, Hyperinsulinemia, Selected Markers of Inflammation: A Randomized Controlled Trial in Adolescents and Young Adults
title_full_unstemmed Effect of Almond Consumption on Metabolic Risk Factors—Glucose Metabolism, Hyperinsulinemia, Selected Markers of Inflammation: A Randomized Controlled Trial in Adolescents and Young Adults
title_short Effect of Almond Consumption on Metabolic Risk Factors—Glucose Metabolism, Hyperinsulinemia, Selected Markers of Inflammation: A Randomized Controlled Trial in Adolescents and Young Adults
title_sort effect of almond consumption on metabolic risk factors—glucose metabolism, hyperinsulinemia, selected markers of inflammation: a randomized controlled trial in adolescents and young adults
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264510/
https://www.ncbi.nlm.nih.gov/pubmed/34249987
http://dx.doi.org/10.3389/fnut.2021.668622
work_keys_str_mv AT madanjagmeet effectofalmondconsumptiononmetabolicriskfactorsglucosemetabolismhyperinsulinemiaselectedmarkersofinflammationarandomizedcontrolledtrialinadolescentsandyoungadults
AT desaisharvari effectofalmondconsumptiononmetabolicriskfactorsglucosemetabolismhyperinsulinemiaselectedmarkersofinflammationarandomizedcontrolledtrialinadolescentsandyoungadults
AT moitrapanchali effectofalmondconsumptiononmetabolicriskfactorsglucosemetabolismhyperinsulinemiaselectedmarkersofinflammationarandomizedcontrolledtrialinadolescentsandyoungadults
AT salissheryl effectofalmondconsumptiononmetabolicriskfactorsglucosemetabolismhyperinsulinemiaselectedmarkersofinflammationarandomizedcontrolledtrialinadolescentsandyoungadults
AT agasheshubhada effectofalmondconsumptiononmetabolicriskfactorsglucosemetabolismhyperinsulinemiaselectedmarkersofinflammationarandomizedcontrolledtrialinadolescentsandyoungadults
AT battalwarrekha effectofalmondconsumptiononmetabolicriskfactorsglucosemetabolismhyperinsulinemiaselectedmarkersofinflammationarandomizedcontrolledtrialinadolescentsandyoungadults
AT mehtaanushree effectofalmondconsumptiononmetabolicriskfactorsglucosemetabolismhyperinsulinemiaselectedmarkersofinflammationarandomizedcontrolledtrialinadolescentsandyoungadults
AT kamblerachana effectofalmondconsumptiononmetabolicriskfactorsglucosemetabolismhyperinsulinemiaselectedmarkersofinflammationarandomizedcontrolledtrialinadolescentsandyoungadults
AT kalitasoumik effectofalmondconsumptiononmetabolicriskfactorsglucosemetabolismhyperinsulinemiaselectedmarkersofinflammationarandomizedcontrolledtrialinadolescentsandyoungadults
AT phatakajaygajanan effectofalmondconsumptiononmetabolicriskfactorsglucosemetabolismhyperinsulinemiaselectedmarkersofinflammationarandomizedcontrolledtrialinadolescentsandyoungadults
AT udipishobhaa effectofalmondconsumptiononmetabolicriskfactorsglucosemetabolismhyperinsulinemiaselectedmarkersofinflammationarandomizedcontrolledtrialinadolescentsandyoungadults
AT vaidyaramaa effectofalmondconsumptiononmetabolicriskfactorsglucosemetabolismhyperinsulinemiaselectedmarkersofinflammationarandomizedcontrolledtrialinadolescentsandyoungadults
AT vaidyaashokb effectofalmondconsumptiononmetabolicriskfactorsglucosemetabolismhyperinsulinemiaselectedmarkersofinflammationarandomizedcontrolledtrialinadolescentsandyoungadults