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The Stroke Neuro-Imaging Phenotype Repository: An Open Data Science Platform for Stroke Research

Stroke is one of the leading causes of death and disability worldwide. Reducing this disease burden through drug discovery and evaluation of stroke patient outcomes requires broader characterization of stroke pathophysiology, yet the underlying biologic and genetic factors contributing to outcomes a...

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Autores principales: Mohammadian Foroushani, Hossein, Dhar, Rajat, Chen, Yasheng, Gurney, Jenny, Hamzehloo, Ali, Lee, Jin-Moo, Marcus, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264586/
https://www.ncbi.nlm.nih.gov/pubmed/34248529
http://dx.doi.org/10.3389/fninf.2021.597708
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author Mohammadian Foroushani, Hossein
Dhar, Rajat
Chen, Yasheng
Gurney, Jenny
Hamzehloo, Ali
Lee, Jin-Moo
Marcus, Daniel S.
author_facet Mohammadian Foroushani, Hossein
Dhar, Rajat
Chen, Yasheng
Gurney, Jenny
Hamzehloo, Ali
Lee, Jin-Moo
Marcus, Daniel S.
author_sort Mohammadian Foroushani, Hossein
collection PubMed
description Stroke is one of the leading causes of death and disability worldwide. Reducing this disease burden through drug discovery and evaluation of stroke patient outcomes requires broader characterization of stroke pathophysiology, yet the underlying biologic and genetic factors contributing to outcomes are largely unknown. Remedying this critical knowledge gap requires deeper phenotyping, including large-scale integration of demographic, clinical, genomic, and imaging features. Such big data approaches will be facilitated by developing and running processing pipelines to extract stroke-related phenotypes at large scale. Millions of stroke patients undergo routine brain imaging each year, capturing a rich set of data on stroke-related injury and outcomes. The Stroke Neuroimaging Phenotype Repository (SNIPR) was developed as a multi-center centralized imaging repository of clinical computed tomography (CT) and magnetic resonance imaging (MRI) scans from stroke patients worldwide, based on the open source XNAT imaging informatics platform. The aims of this repository are to: (i) store, manage, process, and facilitate sharing of high-value stroke imaging data sets, (ii) implement containerized automated computational methods to extract image characteristics and disease-specific features from contributed images, (iii) facilitate integration of imaging, genomic, and clinical data to perform large-scale analysis of complications after stroke; and (iv) develop SNIPR as a collaborative platform aimed at both data scientists and clinical investigators. Currently, SNIPR hosts research projects encompassing ischemic and hemorrhagic stroke, with data from 2,246 subjects, and 6,149 imaging sessions from Washington University’s clinical image archive as well as contributions from collaborators in different countries, including Finland, Poland, and Spain. Moreover, we have extended the XNAT data model to include relevant clinical features, including subject demographics, stroke severity (NIH Stroke Scale), stroke subtype (using TOAST classification), and outcome [modified Rankin Scale (mRS)]. Image processing pipelines are deployed on SNIPR using containerized modules, which facilitate replicability at a large scale. The first such pipeline identifies axial brain CT scans from DICOM header data and image data using a meta deep learning scan classifier, registers serial scans to an atlas, segments tissue compartments, and calculates CSF volume. The resulting volume can be used to quantify the progression of cerebral edema after ischemic stroke. SNIPR thus enables the development and validation of pipelines to automatically extract imaging phenotypes and couple them with clinical data with the overarching aim of enabling a broad understanding of stroke progression and outcomes.
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spelling pubmed-82645862021-07-09 The Stroke Neuro-Imaging Phenotype Repository: An Open Data Science Platform for Stroke Research Mohammadian Foroushani, Hossein Dhar, Rajat Chen, Yasheng Gurney, Jenny Hamzehloo, Ali Lee, Jin-Moo Marcus, Daniel S. Front Neuroinform Neuroinformatics Stroke is one of the leading causes of death and disability worldwide. Reducing this disease burden through drug discovery and evaluation of stroke patient outcomes requires broader characterization of stroke pathophysiology, yet the underlying biologic and genetic factors contributing to outcomes are largely unknown. Remedying this critical knowledge gap requires deeper phenotyping, including large-scale integration of demographic, clinical, genomic, and imaging features. Such big data approaches will be facilitated by developing and running processing pipelines to extract stroke-related phenotypes at large scale. Millions of stroke patients undergo routine brain imaging each year, capturing a rich set of data on stroke-related injury and outcomes. The Stroke Neuroimaging Phenotype Repository (SNIPR) was developed as a multi-center centralized imaging repository of clinical computed tomography (CT) and magnetic resonance imaging (MRI) scans from stroke patients worldwide, based on the open source XNAT imaging informatics platform. The aims of this repository are to: (i) store, manage, process, and facilitate sharing of high-value stroke imaging data sets, (ii) implement containerized automated computational methods to extract image characteristics and disease-specific features from contributed images, (iii) facilitate integration of imaging, genomic, and clinical data to perform large-scale analysis of complications after stroke; and (iv) develop SNIPR as a collaborative platform aimed at both data scientists and clinical investigators. Currently, SNIPR hosts research projects encompassing ischemic and hemorrhagic stroke, with data from 2,246 subjects, and 6,149 imaging sessions from Washington University’s clinical image archive as well as contributions from collaborators in different countries, including Finland, Poland, and Spain. Moreover, we have extended the XNAT data model to include relevant clinical features, including subject demographics, stroke severity (NIH Stroke Scale), stroke subtype (using TOAST classification), and outcome [modified Rankin Scale (mRS)]. Image processing pipelines are deployed on SNIPR using containerized modules, which facilitate replicability at a large scale. The first such pipeline identifies axial brain CT scans from DICOM header data and image data using a meta deep learning scan classifier, registers serial scans to an atlas, segments tissue compartments, and calculates CSF volume. The resulting volume can be used to quantify the progression of cerebral edema after ischemic stroke. SNIPR thus enables the development and validation of pipelines to automatically extract imaging phenotypes and couple them with clinical data with the overarching aim of enabling a broad understanding of stroke progression and outcomes. Frontiers Media S.A. 2021-06-24 /pmc/articles/PMC8264586/ /pubmed/34248529 http://dx.doi.org/10.3389/fninf.2021.597708 Text en Copyright © 2021 Mohammadian Foroushani, Dhar, Chen, Gurney, Hamzehloo, Lee and Marcus. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroinformatics
Mohammadian Foroushani, Hossein
Dhar, Rajat
Chen, Yasheng
Gurney, Jenny
Hamzehloo, Ali
Lee, Jin-Moo
Marcus, Daniel S.
The Stroke Neuro-Imaging Phenotype Repository: An Open Data Science Platform for Stroke Research
title The Stroke Neuro-Imaging Phenotype Repository: An Open Data Science Platform for Stroke Research
title_full The Stroke Neuro-Imaging Phenotype Repository: An Open Data Science Platform for Stroke Research
title_fullStr The Stroke Neuro-Imaging Phenotype Repository: An Open Data Science Platform for Stroke Research
title_full_unstemmed The Stroke Neuro-Imaging Phenotype Repository: An Open Data Science Platform for Stroke Research
title_short The Stroke Neuro-Imaging Phenotype Repository: An Open Data Science Platform for Stroke Research
title_sort stroke neuro-imaging phenotype repository: an open data science platform for stroke research
topic Neuroinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264586/
https://www.ncbi.nlm.nih.gov/pubmed/34248529
http://dx.doi.org/10.3389/fninf.2021.597708
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