Normal Numbers of Stem Cell Memory T Cells Despite Strongly Reduced Naive T Cells Support Intact Memory T Cell Compartment in Ataxia Telangiectasia

Ataxia Telangiectasia (AT) is a rare inherited disorder characterized by progressive cerebellar ataxia, chromosomal instability, cancer susceptibility and immunodeficiency. AT is caused by mutations in the ATM gene, which is involved in multiple processes linked to DNA double strand break repair. Im...

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Detalles Bibliográficos
Autores principales: Weitering, Thomas J., Melsen, Janine E., van Ostaijen-ten Dam, Monique M., Weemaes, Corry M. R., Schilham, Marco W., van der Burg, Mirjam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264762/
https://www.ncbi.nlm.nih.gov/pubmed/34248969
http://dx.doi.org/10.3389/fimmu.2021.686333

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