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Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness
Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264966/ https://www.ncbi.nlm.nih.gov/pubmed/34236619 http://dx.doi.org/10.1007/s12028-021-01260-x |
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| author | Claassen, Jan Akbari, Yama Alexander, Sheila Bader, Mary Kay Bell, Kathleen Bleck, Thomas P. Boly, Melanie Brown, Jeremy Chou, Sherry H.-Y. Diringer, Michael N. Edlow, Brian L. Foreman, Brandon Giacino, Joseph T. Gosseries, Olivia Green, Theresa Greer, David M. Hanley, Daniel F. Hartings, Jed A. Helbok, Raimund Hemphill, J. Claude Hinson, H. E. Hirsch, Karen Human, Theresa James, Michael L. Ko, Nerissa Kondziella, Daniel Livesay, Sarah Madden, Lori K. Mainali, Shraddha Mayer, Stephan A. McCredie, Victoria McNett, Molly M. Meyfroidt, Geert Monti, Martin M. Muehlschlegel, Susanne Murthy, Santosh Nyquist, Paul Olson, DaiWai M. Provencio, J. Javier Rosenthal, Eric Sampaio Silva, Gisele Sarasso, Simone Schiff, Nicholas D. Sharshar, Tarek Shutter, Lori Stevens, Robert D. Vespa, Paul Videtta, Walter Wagner, Amy Ziai, Wendy Whyte, John Zink, Elizabeth Suarez, Jose I. |
| author_facet | Claassen, Jan Akbari, Yama Alexander, Sheila Bader, Mary Kay Bell, Kathleen Bleck, Thomas P. Boly, Melanie Brown, Jeremy Chou, Sherry H.-Y. Diringer, Michael N. Edlow, Brian L. Foreman, Brandon Giacino, Joseph T. Gosseries, Olivia Green, Theresa Greer, David M. Hanley, Daniel F. Hartings, Jed A. Helbok, Raimund Hemphill, J. Claude Hinson, H. E. Hirsch, Karen Human, Theresa James, Michael L. Ko, Nerissa Kondziella, Daniel Livesay, Sarah Madden, Lori K. Mainali, Shraddha Mayer, Stephan A. McCredie, Victoria McNett, Molly M. Meyfroidt, Geert Monti, Martin M. Muehlschlegel, Susanne Murthy, Santosh Nyquist, Paul Olson, DaiWai M. Provencio, J. Javier Rosenthal, Eric Sampaio Silva, Gisele Sarasso, Simone Schiff, Nicholas D. Sharshar, Tarek Shutter, Lori Stevens, Robert D. Vespa, Paul Videtta, Walter Wagner, Amy Ziai, Wendy Whyte, John Zink, Elizabeth Suarez, Jose I. |
| author_sort | Claassen, Jan |
| collection | PubMed |
| description | Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12028-021-01260-x. |
| format | Online Article Text |
| id | pubmed-8264966 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Springer US |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-82649662021-07-09 Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness Claassen, Jan Akbari, Yama Alexander, Sheila Bader, Mary Kay Bell, Kathleen Bleck, Thomas P. Boly, Melanie Brown, Jeremy Chou, Sherry H.-Y. Diringer, Michael N. Edlow, Brian L. Foreman, Brandon Giacino, Joseph T. Gosseries, Olivia Green, Theresa Greer, David M. Hanley, Daniel F. Hartings, Jed A. Helbok, Raimund Hemphill, J. Claude Hinson, H. E. Hirsch, Karen Human, Theresa James, Michael L. Ko, Nerissa Kondziella, Daniel Livesay, Sarah Madden, Lori K. Mainali, Shraddha Mayer, Stephan A. McCredie, Victoria McNett, Molly M. Meyfroidt, Geert Monti, Martin M. Muehlschlegel, Susanne Murthy, Santosh Nyquist, Paul Olson, DaiWai M. Provencio, J. Javier Rosenthal, Eric Sampaio Silva, Gisele Sarasso, Simone Schiff, Nicholas D. Sharshar, Tarek Shutter, Lori Stevens, Robert D. Vespa, Paul Videtta, Walter Wagner, Amy Ziai, Wendy Whyte, John Zink, Elizabeth Suarez, Jose I. Neurocrit Care The Curing Coma Campaign Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12028-021-01260-x. Springer US 2021-07-08 2021 /pmc/articles/PMC8264966/ /pubmed/34236619 http://dx.doi.org/10.1007/s12028-021-01260-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | The Curing Coma Campaign Claassen, Jan Akbari, Yama Alexander, Sheila Bader, Mary Kay Bell, Kathleen Bleck, Thomas P. Boly, Melanie Brown, Jeremy Chou, Sherry H.-Y. Diringer, Michael N. Edlow, Brian L. Foreman, Brandon Giacino, Joseph T. Gosseries, Olivia Green, Theresa Greer, David M. Hanley, Daniel F. Hartings, Jed A. Helbok, Raimund Hemphill, J. Claude Hinson, H. E. Hirsch, Karen Human, Theresa James, Michael L. Ko, Nerissa Kondziella, Daniel Livesay, Sarah Madden, Lori K. Mainali, Shraddha Mayer, Stephan A. McCredie, Victoria McNett, Molly M. Meyfroidt, Geert Monti, Martin M. Muehlschlegel, Susanne Murthy, Santosh Nyquist, Paul Olson, DaiWai M. Provencio, J. Javier Rosenthal, Eric Sampaio Silva, Gisele Sarasso, Simone Schiff, Nicholas D. Sharshar, Tarek Shutter, Lori Stevens, Robert D. Vespa, Paul Videtta, Walter Wagner, Amy Ziai, Wendy Whyte, John Zink, Elizabeth Suarez, Jose I. Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness |
| title | Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness |
| title_full | Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness |
| title_fullStr | Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness |
| title_full_unstemmed | Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness |
| title_short | Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness |
| title_sort | proceedings of the first curing coma campaign nih symposium: challenging the future of research for coma and disorders of consciousness |
| topic | The Curing Coma Campaign |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264966/ https://www.ncbi.nlm.nih.gov/pubmed/34236619 http://dx.doi.org/10.1007/s12028-021-01260-x |
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