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Acute pre-operative ibuprofen improves cognition in a rat model for postoperative cognitive dysfunction

BACKGROUND: Inflammation is considered a key factor in the development of postoperative cognitive dysfunction (POCD). Therefore, we hypothesized that pre-operative anti-inflammatory treatment with ibuprofen would inhibit POCD in our rat-model. METHODS: Male Wistar rats of 3 or 23 months old received...

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Detalles Bibliográficos
Autores principales:	Oberman, Klaske, Hovens, Iris, de Haan, Jacco, Falcao-Salles, Joana, van Leeuwen, Barbara, Schoemaker, Regien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265047/ https://www.ncbi.nlm.nih.gov/pubmed/34238316 http://dx.doi.org/10.1186/s12974-021-02206-y

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