Cargando…
Duration of basic and attenuated-psychotic symptoms in individuals at clinical high risk for psychosis: pattern of symptom onset and effects of duration on functioning and cognition
INTRODUCTION: Duration of risk symptoms (DUR) in people at clinical high risk for psychosis (CHR-P) has been related to poorer clinical outcomes, such as reduced functioning, but it is currently unclear how different symptoms emerge as well as their link with cognitive deficits. To address these que...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265048/ https://www.ncbi.nlm.nih.gov/pubmed/34233651 http://dx.doi.org/10.1186/s12888-021-03267-2 |
_version_ | 1783719690461249536 |
---|---|
author | Staines, Lorna Gajwani, Ruchika Gross, Joachim Gumley, Andrew I. Lawrie, Stephen M. Schwannauer, Matthias Schultze-Lutter, Frauke Uhlhaas, Peter J. |
author_facet | Staines, Lorna Gajwani, Ruchika Gross, Joachim Gumley, Andrew I. Lawrie, Stephen M. Schwannauer, Matthias Schultze-Lutter, Frauke Uhlhaas, Peter J. |
author_sort | Staines, Lorna |
collection | PubMed |
description | INTRODUCTION: Duration of risk symptoms (DUR) in people at clinical high risk for psychosis (CHR-P) has been related to poorer clinical outcomes, such as reduced functioning, but it is currently unclear how different symptoms emerge as well as their link with cognitive deficits. To address these questions, we examined the duration of basic symptoms (BS) and attenuated psychotic symptoms (APS) in a sample of CHR-P participants to test the hypothesis that BS precede the manifestation of APS. As a secondary objective, we investigated the relationship between DUR, functioning and neuropsychological deficits. METHODS: Data from 134 CHR-P participants were assessed with the Comprehensive Assessment of At-Risk Mental State and the Schizophrenia Proneness Interview, Adult Version. Global, role and social functioning and neurocognition were assessed and compared to a sample of healthy controls (n = 57). RESULTS: In CHR-P participants who reported both APS and BS, onset of BS and APS was not significantly related. When divided into short and long BS duration (</> 8 years), CHR-P participants with a longer duration of BS showed evidence for an onset of BS preceding APS (n = 8, p = 0.003). However, in the short BS duration group, APS showed evidence of preceding BS (n = 56, p = 0.020). Finally, there were no significant effects of DUR on cognition or functioning measures. CONCLUSION: The present findings do not support the view that APS constitute a secondary phenomenon to BS. Moreover, our data could also not confirm that DUR has a significant effect on functioning and cognitive deficits. These findings are discussed in the context of current theories regarding emerging psychosis and the importance of DUR. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-021-03267-2. |
format | Online Article Text |
id | pubmed-8265048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82650482021-07-08 Duration of basic and attenuated-psychotic symptoms in individuals at clinical high risk for psychosis: pattern of symptom onset and effects of duration on functioning and cognition Staines, Lorna Gajwani, Ruchika Gross, Joachim Gumley, Andrew I. Lawrie, Stephen M. Schwannauer, Matthias Schultze-Lutter, Frauke Uhlhaas, Peter J. BMC Psychiatry Research INTRODUCTION: Duration of risk symptoms (DUR) in people at clinical high risk for psychosis (CHR-P) has been related to poorer clinical outcomes, such as reduced functioning, but it is currently unclear how different symptoms emerge as well as their link with cognitive deficits. To address these questions, we examined the duration of basic symptoms (BS) and attenuated psychotic symptoms (APS) in a sample of CHR-P participants to test the hypothesis that BS precede the manifestation of APS. As a secondary objective, we investigated the relationship between DUR, functioning and neuropsychological deficits. METHODS: Data from 134 CHR-P participants were assessed with the Comprehensive Assessment of At-Risk Mental State and the Schizophrenia Proneness Interview, Adult Version. Global, role and social functioning and neurocognition were assessed and compared to a sample of healthy controls (n = 57). RESULTS: In CHR-P participants who reported both APS and BS, onset of BS and APS was not significantly related. When divided into short and long BS duration (</> 8 years), CHR-P participants with a longer duration of BS showed evidence for an onset of BS preceding APS (n = 8, p = 0.003). However, in the short BS duration group, APS showed evidence of preceding BS (n = 56, p = 0.020). Finally, there were no significant effects of DUR on cognition or functioning measures. CONCLUSION: The present findings do not support the view that APS constitute a secondary phenomenon to BS. Moreover, our data could also not confirm that DUR has a significant effect on functioning and cognitive deficits. These findings are discussed in the context of current theories regarding emerging psychosis and the importance of DUR. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-021-03267-2. BioMed Central 2021-07-07 /pmc/articles/PMC8265048/ /pubmed/34233651 http://dx.doi.org/10.1186/s12888-021-03267-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Staines, Lorna Gajwani, Ruchika Gross, Joachim Gumley, Andrew I. Lawrie, Stephen M. Schwannauer, Matthias Schultze-Lutter, Frauke Uhlhaas, Peter J. Duration of basic and attenuated-psychotic symptoms in individuals at clinical high risk for psychosis: pattern of symptom onset and effects of duration on functioning and cognition |
title | Duration of basic and attenuated-psychotic symptoms in individuals at clinical high risk for psychosis: pattern of symptom onset and effects of duration on functioning and cognition |
title_full | Duration of basic and attenuated-psychotic symptoms in individuals at clinical high risk for psychosis: pattern of symptom onset and effects of duration on functioning and cognition |
title_fullStr | Duration of basic and attenuated-psychotic symptoms in individuals at clinical high risk for psychosis: pattern of symptom onset and effects of duration on functioning and cognition |
title_full_unstemmed | Duration of basic and attenuated-psychotic symptoms in individuals at clinical high risk for psychosis: pattern of symptom onset and effects of duration on functioning and cognition |
title_short | Duration of basic and attenuated-psychotic symptoms in individuals at clinical high risk for psychosis: pattern of symptom onset and effects of duration on functioning and cognition |
title_sort | duration of basic and attenuated-psychotic symptoms in individuals at clinical high risk for psychosis: pattern of symptom onset and effects of duration on functioning and cognition |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265048/ https://www.ncbi.nlm.nih.gov/pubmed/34233651 http://dx.doi.org/10.1186/s12888-021-03267-2 |
work_keys_str_mv | AT staineslorna durationofbasicandattenuatedpsychoticsymptomsinindividualsatclinicalhighriskforpsychosispatternofsymptomonsetandeffectsofdurationonfunctioningandcognition AT gajwaniruchika durationofbasicandattenuatedpsychoticsymptomsinindividualsatclinicalhighriskforpsychosispatternofsymptomonsetandeffectsofdurationonfunctioningandcognition AT grossjoachim durationofbasicandattenuatedpsychoticsymptomsinindividualsatclinicalhighriskforpsychosispatternofsymptomonsetandeffectsofdurationonfunctioningandcognition AT gumleyandrewi durationofbasicandattenuatedpsychoticsymptomsinindividualsatclinicalhighriskforpsychosispatternofsymptomonsetandeffectsofdurationonfunctioningandcognition AT lawriestephenm durationofbasicandattenuatedpsychoticsymptomsinindividualsatclinicalhighriskforpsychosispatternofsymptomonsetandeffectsofdurationonfunctioningandcognition AT schwannauermatthias durationofbasicandattenuatedpsychoticsymptomsinindividualsatclinicalhighriskforpsychosispatternofsymptomonsetandeffectsofdurationonfunctioningandcognition AT schultzelutterfrauke durationofbasicandattenuatedpsychoticsymptomsinindividualsatclinicalhighriskforpsychosispatternofsymptomonsetandeffectsofdurationonfunctioningandcognition AT uhlhaaspeterj durationofbasicandattenuatedpsychoticsymptomsinindividualsatclinicalhighriskforpsychosispatternofsymptomonsetandeffectsofdurationonfunctioningandcognition |